{"product_id":"abcam-ab101688","title":"Abcam, ab101688, Anti-Progesterone Receptor antibody [SP42]","description":"\u003cp\u003eSize: 100µL \/ 500µL \/ 1mL\u003cbr\u003e\nAnti-Progesterone Receptor antibody [SP42] (ab101688) is a rabbit monoclonal antibody detecting Progesterone Receptor in  Flow Cytometry, IHC-P, ICC\/IF . Suitable for  Human, Mouse, Rat . - Biophysical QC for unrivalled batch-batch consistency - Trusted since 2010\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:SP42,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IHC-P, Flow Cyt, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-RAB10 antibody [MJF-R23] (\u003cbr\u003e\nab237703\u003cbr\u003e\n) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Intra), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunocytochemistry\/immunofluorescence (ICC\/IF) in Human, Mouse, Rat samples.\u003cbr\u003e\nWhat is the molecular weight of RAB10?\u003cbr\u003e\nAnti-RAB10 [MJF-R23] (\u003cbr\u003e\nab237703\u003cbr\u003e\n) specifically detects a band for RAB10 (UniProt: P61026) at a molecular weight of 22kDa.\u003cbr\u003e\nTrusted by the scientific community\u003cbr\u003e\nAnti-RAB10 [MJF-R23] (\u003cbr\u003e\nab237703\u003cbr\u003e\n) was first used in a scientific publication in 2018 and has been cited over 20 times in peer-reviewed journals.\u003cbr\u003e\nTrial sizes available!\u003cbr\u003e\nTest your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.\u003cbr\u003e\nDiscover our selection of trial-size antibodies\u003cbr\u003e\nSpecificity confirmed\u003cbr\u003e\nThe specificity of Anti-RAB10 antibody [MJF-R23] (\u003cbr\u003e\nab237703\u003cbr\u003e\n) has been confirmed by Immunocytochemistry testing in RAB10 Knockout A549 cells.\u003cbr\u003e\nOther related products\u003cbr\u003e\nWe have a range of other formats of antibody clone [MJF-R23] also available for your convenience:\u003cbr\u003e\nab237703\u003cbr\u003e\n, Carrier free -\u003cbr\u003e\nab238655\u003cbr\u003e\n, Alexa Fluor® 488 -\u003cbr\u003e\nab302654\u003cbr\u003e\n, Alexa Fluor® 647 -\u003cbr\u003e\nab302699\u003cbr\u003e\n, Alexa Fluor® 594 -\u003cbr\u003e\nab302835\u003cbr\u003e\n, Alexa Fluor® 555 -\u003cbr\u003e\nab306567\u003cbr\u003e\nab307296\u003cbr\u003e\n, Carrier free -\u003cbr\u003e\nab307297\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A\/G, Purification notes-Purified from TCS by protein A\/G., Storage buffer-pH: 7.6Preservative: 0.1% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe progesterone receptor (PR) also known as NR3C3 is a nuclear receptor that functions as a transcription factor in response to the hormone progesterone. This receptor has a mass of approximately 99 kDa and is expressed in tissues such as the reproductive organs including the uterus ovaries and mammary glands. It is also found in non-reproductive tissues like the brain and bone. The receptor has two main isoforms PR-A and PR-B which differ slightly in structure but have unique biological roles.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe progesterone receptor plays a significant role in regulating gene expression related to reproductive processes. PR is not part of a larger complex by itself but interacts with various coactivators and corepressors to modulate transcription. In the uterus and mammary glands PR mediates the effects of progesterone by promoting cell proliferation and preparing tissues for pregnancy. In other systems PR also links to various metabolic and immunological pathways influencing cell cycle progression and immune response.\u003cbr\u003e\nPathways\u003cbr\u003e\nProgesterone receptor activity is integrated within the reproductive hormone signaling pathways and the Wnt signaling pathway. The receptor interacts directly with key proteins such as estrogen receptor (ER) and steroid receptor coactivator (SRC) complexes which are pivotal in modulating response to hormonal signals. These interactions underline the essential role of PR in maintaining hormonal balance and regulating reproductive functions.\u003cbr\u003e\nThe progesterone receptor associates with breast cancer and endometriosis. Aberrant expression or mutations in PR can contribute to the development and progression of breast cancer often linked with the estrogen receptor's influence. In endometriosis PR's altered functionality affects cellular response to progesterone contributing to tissue growth outside the uterus. These conditions also involve interactions with proteins like BRCA1 in breast cancer highlighting how PR connects to broader cellular and pathological networks.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844129411241,"sku":"ab101688","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab101688","provider":"Iright","version":"1.0","type":"link"}