{"product_id":"abcam-ab106410","title":"Abcam, ab106410, Anti-PRDM16 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nAnti-PRDM16 antibody (ab106410) is a rabbit polyclonal antibody detecting PRDM16 in  Western Blot, IHC-P . Suitable for  Human, Mouse, Rat . - Over 70 publications\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Rat, Mouse,\u003cbr\u003e\nApplications:WB, ICC, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human PRDM16. The exact immunogen used to generate this antibody is proprietary information.Q9HAZ2,\u003cbr\u003e\nSpecificity:At least four isoforms of PRDM16 are known to exist; ab106410 will recognize all four.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-PRDM16 antibody (ab106410) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P) in Human, Mouse, Rat samples.\u003cbr\u003e\nWhat is the molecular weight of PRDM16?\u003cbr\u003e\nAnti-PRDM16 (ab106410) specifically detects a band for PRDM16 (UniProt: Q9HAZ2) at a molecular weight of 140kDa.\u003cbr\u003e\nTrusted by the scientific community\u003cbr\u003e\nAnti-PRDM16 (ab106410) was first used in a scientific publication in 2011 and has been cited over 70 times in peer-reviewed journals.\u003cbr\u003e\nReviewed by scientists\u003cbr\u003e\nAnti-PRDM16 (ab106410) has over 5 independent reviews from customers.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPRDM16 also known as the PR-domain containing 16 is a transcription cofactor involved in the regulation of genes. It has a mass of approximately 140 kDa. This protein is found in multiple tissues with high expression levels observed in brown adipose tissue and skeletal muscle. PRDM16 regulates gene expression by interacting with other transcription factors and modifying chromatin structure.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPRDM16 is essential in the determination of brown adipose tissue and skeletal muscle differentiation. It belongs to a complex that includes C\/EBPΒ and PPARγ which are pivotal for the conversion of myoblasts into thermogenic brown fat cells. This activity contributes to the generation of cells specialized for heat production which aids in maintaining body temperature.\u003cbr\u003e\nPathways\u003cbr\u003e\nPRDM16 functions are linked to cellular metabolism and thermogenesis. It plays a substantial role in the Wnt\/Β-catenin signaling pathway where it influences energy balance. In this pathway PRDM16 interacts with Wnt signaling regulators and coactivators that control adipocyte differentiation and energy expenditure.\u003cbr\u003e\nPRDM16 plays a role in myoblastic leukemia and obesity-related conditions. Changes in the function or expression of PRDM16 can contribute to pathological transformation leading to leukemia with proteins C\/EBPΒ and PPARγ also involved in related mechanisms. In obesity altered PRDM16 activity affects the formation and function of brown adipose tissue potentially disrupting normal energy metabolism and storage.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845034561705,"sku":"ab106410","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab106410","provider":"Iright","version":"1.0","type":"link"}