{"product_id":"abcam-ab106580","title":"Abcam, ab106580, Anti-VEGF 165A antibody","description":"Size: 100µg\nRabbit Polyclonal VEGFA antibody. Suitable for WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human VEGFA.\nKey facts\nHost species:Rabbit,\nClonality:Polyclonal,\nIsotype:IgG,\nCarrier free:No,\nReacts with:Human,\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\nImmunogen:Recombinant Full Length Protein corresponding to Human VEGFA.P15692,\nSpecificity:In ELISA and other immunoreactive assays, this antibody will recognize both native and recombinant human VEGF-165 in cell supernatants and certain body fluids.  A control of similarly diluted normal rabbit IgG is recommended.\n\nProperties and Storage Information:\nForm-Liquid, Purification technique-Ion exchange chromatography, Purification notes-This product is an IgG fraction antibody purified from monospecific antiserum by a multi-step process which includes delipidation, salt fractionation and ion exchange chromatography followed by extensive dialysis against the buffer. This purified antibody has been heated to 56°C for 30 minutes., Storage buffer-Constituents: 0.88% Sodium chloride, 0.424% Potassium phosphate solution, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\n\nSupplementary Information:\nThis supplementary information is collated from multiple sources and compiled automatically.\nVEGF 165A or Vascular Endothelial Growth Factor 165A is an important protein that plays a role in angiogenesis which is the growth of new blood vessels. Also known as VEGF-A or VEGF isoform 165 this protein has a mass of around 23 kDa when it is in its biotinylated form. VEGF 165A is expressed in various cell types including endothelial cells which form the lining of blood vessels as well as in smooth muscle cells and certain tumor cells. The protein is often targeted in research using anti-VEGF antibodies.\nBiological function summary\nThis protein acts directly on endothelial cells to stimulate their proliferation and migration. VEGF 165A is part of a larger family of VEGF proteins that share similar structures and functions. It plays a critical role in both physiological processes like wound healing and pathological conditions like cancer where its expression becomes dysregulated. The protein can bind to receptors on the cell surface initiating cell signaling pathways that lead to angiogenesis.\nPathways\nVEGF 165A functions prominently in the VEGF signaling pathway and the MAPK\/ERK pathway. Through these pathways it interacts with other proteins such as VEGF receptors particularly VEGFR-2 to propagate signals leading to angiogenesis and increased vascular permeability. These pathways are vital in ensuring that tissues receive an appropriate blood supply under various conditions including growth and repair processes.\nVEGF 165A shows an association with cancer and age-related macular degeneration (AMD). Overexpression of VEGF 165A is linked to tumor growth because it helps form the blood vessels that supply the tumor known as tumor angiogenesis. Similarly in AMD abnormal blood vessel growth driven by VEGF 165A leads to damage in the retina. Anti-VEGF therapies often target this protein to treat these conditions by inhibiting its action on blood vessel formation.\n","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850104131753,"sku":"ab106580","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab106580","provider":"Iright","version":"1.0","type":"link"}