{"product_id":"abcam-ab1072","title":"Abcam, ab1072, Anti-Bovine Papilloma Virus E2 antibody [5H4]","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nMouse Monoclonal VE2 antibody. Suitable for ICC\/IF, IP, ELISA and reacts with Recombinant full length protein - Bovine papillomavirus, Bovine papillomavirus samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Deltapapillomavirus 4 E2.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:5H4,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Bovine papillomavirus,\u003cbr\u003e\nApplications:ELISA, ICC\/IF, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Deltapapillomavirus 4 E2.P03122,\u003cbr\u003e\nEpitope:Conformational\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nBovine Papilloma Virus E2 (BPV E2) is an important regulatory protein involved in the lifecycle of the Bovine Papilloma Virus. It also goes by alternate names such as E2 protein or Papilloma E2 antigen. The E2 protein has a mass of approximately 40 kDa. It is expressed during the early phase of viral infection within the nucleus of infected cells. BPV E2 plays a mechanical role by binding to DNA at specific sequences facilitating viral replication and transcription.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nBPV E2 functions as a transcription factor that regulates the expression of viral genes. It is part of a larger complex with other viral proteins such as E1 with which it cooperates to initiate viral replication. E2’s control over viral gene expression allows it to modulate the virus's ability to replicate and persist in host cells influencing the viral lifecycle and maintenance.\u003cbr\u003e\nPathways\u003cbr\u003e\nBPV E2 is integral in the regulation of pathways related to viral replication and transcription. It is closely involved in the papillomavirus replication pathway interacting with proteins such as E1 to initiate DNA replication. Another relevant pathway includes transcriptional regulation where E2 controls the expression of various viral genes contributing to papillomavirus pathogenesis.\u003cbr\u003e\nBPV E2 is connected to bovine papillomatosis a condition characterized by wart formation in cattle. This disorder arises due to the uncontrolled proliferation of infected cells mediated by the viral replication facilitated by BPV E2. Its interaction with the E1 protein is essential for the viral replication that leads to disease progression. Understanding E2 and its role offers potential insights into therapeutic targets using bovine antibodies and possibly developing anti-papilloma strategies in bovine species.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854786023593,"sku":"ab1072","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab1072","provider":"Iright","version":"1.0","type":"link"}