{"product_id":"abcam-ab108220","title":"Abcam, ab108220, Anti-CYFIP1 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal CYFIP1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human CYFIP1 aa 1200 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human CYFIP1 aa 1200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q7L576\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab108220 was affinity purified using an epitope specific to CYFIP1 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate\/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCYFIP1 also known as cytoplasmic FMR1-interacting protein 1 plays an important role in cellular processes including actin dynamics and translation regulation. This protein which has a mass of approximately 140 kDa interacts with FMRP and links to the ribosome controlling mRNA translation. CYFIP1 is expressed mostly in the brain but is also present in other tissues like blood. Researchers study CYFIP1 to understand its role in neural activity and cellular signaling processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCYFIP1 operates as part of the WAVE regulatory complex which is critical for actin polymerization. This complex facilitates cytoskeletal reorganization essential for cellular movement and morphology. CYFIP1 influences synaptic plasticity an important process in neural signaling and cognitive functions. By interacting with other molecular components CYFIP1 impacts processes like memory formation and learning.\u003cbr\u003e\nPathways\u003cbr\u003e\nCYFIP1 is integral to the Rac1 and Arp2\/3 pathways which directly affect actin filament assembly. In these pathways CYFIP1 interacts with proteins such as NCKAP1 and ABI2 which play roles in the regulation of actin cytoskeleton reorganization. The involvement of CYFIP1 in these pathways highlights its importance in processes that require rapid cytoskeletal changes such as cell migration and synaptic growth.\u003cbr\u003e\nCYFIP1's function draws a connection to neurodevelopmental disorders and schizophrenia. Alterations in the expression of CYFIP1 have been observed in these conditions suggesting a link between its dysregulation and abnormal brain development. Moreover its interaction with the FMRP protein ties it to Fragile X syndrome characterized by cognitive impairment. Research into these associations provides valuable insight into potential therapeutic targets for these complex conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46853954568361,"sku":"ab108220","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab108220","provider":"Iright","version":"1.0","type":"link"}