{"product_id":"abcam-ab108405","title":"Abcam, ab108405, Anti-FRAT1 antibody [EPR3900]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal FRAT1 antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 9 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR3900,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nFRAT1 also known as Frequently Rearranged in Advanced T-cell lymphomas 1 is a regulatory protein involved in the Wnt signaling pathway. It has a molecular mass of approximately 29 kDa. The protein expresses mainly in tissues such as the brain and lymphoid organs. FRAT1 functions as a positive regulator of the Wnt pathway by inhibiting GSK-3 beta leading to the stabilization and accumulation of β-catenin in the cytoplasm and its subsequent translocation into the nucleus. This role is significant in mediating gene transcription related to cell proliferation and differentiation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFRAT1 contributes to cellular and developmental processes. It forms a functional complex with other proteins in the Wnt signaling pathway including Dishevelled proteins and Axin. The interaction within this complex aids in the modulation of β-catenin levels which is a critical step in the transmission of Wnt signals from the cell surface to the nucleus. Its regulation is necessary for maintaining normal developmental processes and cellular homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nFRAT1 plays an important role in the Wnt\/β-catenin signaling and the cell proliferation pathway. It interacts with proteins such as GSK-3 beta and β-catenin directly affecting the progression of Wnt signals. Through this signaling pathway FRAT1 influences cell fate decisions contributing to tissue development and regeneration. The regulation of these pathways by FRAT1 is essential for controlling cellular proliferation and differentiation in various tissues.\u003cbr\u003e\nFRAT1 has been implicated in cancer specifically in the development of certain lymphomas and gliomas. Its overexpression or mutation can lead to dysregulated Wnt\/β-catenin signaling which contributes to tumorigenesis and the progression of these diseases. Additionally alterations in FRAT1 activity may affect proteins like β-catenin which can further influence cancer-associated signaling networks. Understanding the role of FRAT1 in these pathological conditions may offer insights into potential therapeutic targets.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850263417001,"sku":"ab108405","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab108405","provider":"Iright","version":"1.0","type":"link"}