{"product_id":"abcam-ab108595","title":"Abcam, ab108595, Anti-Lamin A + Lamin C antibody [EPR4100] - Nuclear Envelope Marker","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nAnti-Lamin A + Lamin C antibody [EPR4100] - Nuclear Envelope Marker (ab108595) is a rabbit monoclonal antibody detecting Lamin A + Lamin C in  Western Blot, Flow Cytometry (Intra), Flow Cytometry, IP, IHC-P, ICC\/IF . Suitable for  Human . - KO validated for confirmed specificity - Biophysical QC for unrivalled batch-batch consistency - Over 120 publications\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR4100,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), ICC\/IF, WB, IP, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:The antibody recognizes full length Lamin A\/C and the cleaved large unit.We have data to indicate that this antibody gives non-specific staining in IHC with mouse tissues. Based on this we believe the antibody is not suitable for use with mouse samples, as there will be non-specific staining.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nProduct Specifications\u003cbr\u003e\nAnti-Lamin A + Lamin C antibody [EPR4100] - Nuclear Envelope Marker (ab108595) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), ICC\/IF, IHC-P, IP, WB in human samples.\u003cbr\u003e\nAnti-Lamin A + Lamin C antibody [EPR4100] - Nuclear Envelope Marker (ab108595) specifically detects Lamin A + Lamin C (UniProt ID: P02545; Molecular weight: 74kDa) and is sold in 100 µL and 1 mL selling sizes.\u003cbr\u003e\nQuality and Validation\u003cbr\u003e\nAbcam's high quality manufacturing and validation processes ensure Anti-Lamin A + Lamin C antibody [EPR4100] - Nuclear Envelope Marker (ab108595) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility.\u003cbr\u003e\nThe specificity of Anti-Lamin A + Lamin C antibody [EPR4100] - Nuclear Envelope Marker (ab108595) has been confirmed by testing in knockout samples.\u003cbr\u003e\nAnti-Lamin A + Lamin C antibody [EPR4100] - Nuclear Envelope Marker (ab108595) has been cited over 119 times in peer reviewed journals and is trusted by the scientific community.\u003cbr\u003e\nAnti-Lamin A + Lamin C antibody [EPR4100] - Nuclear Envelope Marker (ab108595) has 7 independent reviews from customers.\u003cbr\u003e\nRelated Products\u003cbr\u003e\nConjugation-ready, carrier free format available for antibody clone EPR4100 -\u003cbr\u003e\nab216074\u003cbr\u003e\nAntibody clone EPR4100 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 488, Alexa Fluor® 647, HRP, PE, Alexa Fluor® 594, Alexa Fluor® 555, Alexa Fluor® 750, APC (\u003cbr\u003e\nab185014\u003cbr\u003e\nab193903\u003cbr\u003e\nab193904\u003cbr\u003e\nab210433\u003cbr\u003e\nab215324\u003cbr\u003e\nab320906\u003cbr\u003e\nab320907\u003cbr\u003e\nab320908\u003cbr\u003e\nSpecies reactivity\u003cbr\u003e\nMouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.\u003cbr\u003e\nPlease\u003cbr\u003e\ncontact us\u003cbr\u003e\nfor more information.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nLamin A and Lamin C also known as lamin A\/C are proteins encoded by the LMNA gene. These proteins are key components of the nuclear envelope where they provide structural support and maintain the shape of the nucleus. The lamin A\/C molecule has a molecular weight of approximately 60-70 kDa. Expression of lamin A and lamin C occurs predominantly in differentiated cells where these proteins integrate into the nuclear lamina alongside other lamin molecules like lamin B. Lamin A alone sometimes referred to by designations like 4C11 plays a significant role in mechanical support at a molecular level.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nLamin A\/C proteins play a role in maintaining nuclear stability chromosome organization and gene regulation. They are part of a complex network within the nuclear lamina that includes interactions with proteins and DNA. Lamin A with a molecular weight distinct from other lamins participates in assembling this supportive matrix and contributes to DNA maintenance and repair processes. Their interaction with chromatin and gene expression regulation emphasizes their influence on important cellular functions.\u003cbr\u003e\nPathways\u003cbr\u003e\nLamin A\/C proteins engage in the mechanosensory signaling and DNA damage response pathways. They interact with pathways involving the nuclear envelope structure and have connections to proteins like emerin and nuclear actin. Lamin A's role in these pathways supports its involvement in responding to mechanical stress and preserving genomic integrity highlighting its integration with these cellular processes.\u003cbr\u003e\nMutations in lamin A\/C are linked to disorders such as Hutchinson-Gilford Progeria Syndrome and Emery-Dreifuss Muscular Dystrophy. These conditions highlight the importance of lamin A\/C in cellular stability and nuclear integrity. Proteins such as emerin often relate to lamin A\/C in these diseases as disruptions to their interactions can lead to compromised nuclear function and disease phenotypes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844029599913,"sku":"ab108595","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab108595","provider":"Iright","version":"1.0","type":"link"}