{"product_id":"abcam-ab108967","title":"Abcam, ab108967, Anti-Talin 2 antibody [EPR2536(2)]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal Talin 2 antibody. Suitable for WB and reacts with Mouse, Rat, African green monkey, Human samples. Cited in 4 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR2536(2),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human, African green monkey,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTalin 2 also known as TLN2 is a large cytoskeletal protein approximately 270 kDa in mass. It acts mechanically as an important player in linking integrins to the actin cytoskeleton supporting the structural integrity of cells. Talin 2 is expressed in various tissues including muscle and neuronal systems with expression patterns similar to Talin 1 but has distinct roles in cellular adhesion and signal transduction.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTalin 2 plays a significant role in cell adhesion and migration processes. It is part of a complex that includes integrins and other cytoskeletal proteins facilitating the transmission of mechanical signals across the cell membrane. This protein aids in focal adhesion assembly ensuring proper cellular responses to external stimuli. Talin 2 contributes to stabilizing intracellular interactions which are essential for maintaining tissue structure and cell motility.\u003cbr\u003e\nPathways\u003cbr\u003e\nTalin 2 is deeply embedded in integrin-mediated signaling and the cytoskeletal organization pathway. It modulates interactions between integrins and F-actin orchestrating actin dynamics and contributing to cellular adherence junctions. Talin 2 functions closely with proteins like vinculin which supports actin filament linkage and reinforces mechanical stability under tension.\u003cbr\u003e\nTalin 2 has been linked to muscular dystrophies and certain neuropathies. Mutations or dysregulation in Talin 2 can impair muscle function as its interaction with dystrophin is critical for muscle integrity. Additionally disruptions in Talin 2 mediated signaling could contribute to neurodegenerative disorders where its interactions with integrins can affect neuronal connectivity and survival. Understanding Talin 2's role in these conditions may provide insights for therapeutic interventions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850333573289,"sku":"ab108967","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab108967","provider":"Iright","version":"1.0","type":"link"}