{"product_id":"abcam-ab110227","title":"Abcam, ab110227, Anti-HSV1 gH antibody [BBH1]","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nMouse Monoclonal GH antibody. Suitable for WB, IP, ICC\/IF, IHC-P and reacts with Transfected cell lysate - Herpes simplex virus, Transfected cell line - Herpes simplex virus samples. Cited in 5 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:BBH1,\u003cbr\u003e\nIsotype:IgG2a,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Herpes simplex virus,\u003cbr\u003e\nApplications:IHC-P, IP, ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:Cross-reactivity has not been checked and this antibody might cross with HSV-2 gH.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product has switched from a hybridoma to recombinant production method on 27th October 2023.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHSV1 gH also known as glycoprotein H is a significant component of the Herpes Simplex Virus type 1 (HSV-1). The glycoprotein has a molecular mass of approximately 93 kDa and is expressed on the viral envelope. It plays a vital role in the virus's ability to infect host cells. Glycoprotein H functions by facilitating the fusion of the viral envelope with the host cell membrane a critical step for viral entry. Besides its primary expression in HSV-1 this protein shares similarities with entry proteins in other herpesviruses indicating its conserved role across different species.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGlycoprotein H functions as part of the glycoprotein H-L complex which includes glycoproteins H L and D. This complex orchestrates the fusion process necessary for the virus to penetrate and infect host cells. The glycoprotein H is vital for the stabilization of the complex and contributes to the proper implementation of viral infection processes. Distribution of this protein in the host organism occurs predominantly in epithelial cells which often serve as the initial site of infection. This distribution aids in the rapid spread of the virus within the host.\u003cbr\u003e\nPathways\u003cbr\u003e\nGlycoprotein H is important for the viral entry pathway. The entry involves interactions with host cell surface receptors that mediate viral attachment and fusion. This process places glycoprotein H within the larger context of viral lifecycle pathways interlinked with proteins such as glycoprotein B and glycoprotein D which assist in initial viral attachment and binding to host cells. The coordination among these proteins ensures efficient viral penetration and subsequent replication within the host.\u003cbr\u003e\nHSV1 gH has a direct connection to herpes simplex infections particularly oral and genital herpes. Its role in viral entry makes it a target for therapeutic interventions aimed at preventing herpesvirus infections. Antibodies targeting glycoprotein H and related viral components can serve as potential treatments by inhibiting virus attachment and entry. Given its role in immune recognition interactions between glycoprotein H and immune cells provide insights into the development of strategies against viral persistence and reactivation particularly in individuals with compromised immune systems.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855376863401,"sku":"ab110227","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab110227","provider":"Iright","version":"1.0","type":"link"}