{"product_id":"abcam-ab110389","title":"Abcam, ab110389, Anti-TIPE2 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal TIPE2 antibody. Suitable for WB and reacts with Human samples. Cited in 15 publications. Immunogen corresponding to Synthetic Peptide within Human TNFAIP8L2.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human TNFAIP8L2. The exact immunogen used to generate this antibody is proprietary information.Q6P589\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTIPE2 also known as TNFAIP8L2 is a member of the TNFAIP8 family of proteins with a molecular mass of approximately 23 kDa. Mechanically TIPE2 acts as a regulator of cell death and survival processes playing a role in modulating immune responses. It is expressed in a variety of tissues but particularly abundant in immune-related cells such as macrophages and lymphocytes. The protein influences signaling pathways by interacting with other molecules in the cell affecting downstream responses.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTIPE2 functions as a negative regulator of immune signaling pathways providing a check against excessive immune activation. It is a cytosolic protein that does not form part of a larger protein complex but can interact with membrane-associated signaling proteins. TIPE2 inhibits both NF-kB and MAPK signaling pathways which are important in mediating immune responses and inflammation. This regulatory function is essential for maintaining immune homeostasis and preventing inflammatory disorders.\u003cbr\u003e\nPathways\u003cbr\u003e\nResearch has highlighted that TIPE2 is integrated within immune signaling cascades particularly impacting the NF-kB and MAPK pathways. These pathways play pivotal roles in inflammation and immune system activation. TIPE2 acts to inhibit the activation of proteins like IKK and JNK which are key mediators within these pathways. By suppressing these pathways TIPE2 helps to balance immune responses and prevent overactivation that can lead to disease states.\u003cbr\u003e\nTIPE2 has been associated with autoimmune diseases and cancer. Insufficient TIPE2 expression or function can lead to autoimmune disorders like rheumatoid arthritis where unchecked immune signaling causes tissue damage. Conversely overexpression might contribute to cancer progression by dampening anti-tumor immune responses. TIPE2’s interaction with TNFAIP8 family proteins has shown implications in tumor progression highlighting its dual role in modulating immune responses and potential for therapeutic targeting.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854407684265,"sku":"ab110389","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab110389","provider":"Iright","version":"1.0","type":"link"}