{"product_id":"abcam-ab113264","title":"Abcam, ab113264, Anti-Mkl1\/MRTFA antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal Mkl1\/MRTFA antibody. Suitable for IHC-P and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Human MRTFA aa 700-750.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human MRTFA aa 700-750. The exact immunogen used to generate this antibody is proprietary information.Q969V6\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: 99% Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMkl1 also known as MRTFA is a transcriptional coactivator that plays a role in regulating gene expression. It has a molecular weight of approximately 142 kDa. Mkl1 is widely expressed in various tissues including the heart lung and skeletal muscle. As a coactivator it interacts with serum response factor (SRF) to facilitate the transcription of target genes involved in cytoskeletal dynamics and cell differentiation processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMkl1 is important in the regulation of actin cytoskeleton remodeling. It does not act alone; it forms part of a dynamic complex with actin monomers. These interactions are essential for the modulation of gene transcription. Mkl1 binds to gene promoters enabling transcriptional activation in response to cellular signals that involve changes in actin polymerization.\u003cbr\u003e\nPathways\u003cbr\u003e\nMkl1 integrates into the RhoA signaling pathway and the Hippo pathway important for cytoskeleton organization and cell growth control respectively. Within these pathways Mkl1 regulates the activity of SRF coordinating cellular responses to mechanical stress and environmental stimuli. Mkl1 also interacts with other proteins such as myocardin and its family members which are relevant in smooth muscle cell differentiation.\u003cbr\u003e\nMutated or dysregulated Mkl1 has been connected to certain leukemias particularly acute megakaryoblastic leukemia. It also relates to cardiac hypertrophy a condition associated with abnormal heart muscle growth. Mkl1 dysregulation leads to altered SRF pathway activity impacting the expression of genes involved in cell growth and differentiation which is critical in these disease processes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854362005673,"sku":"ab113264","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab113264","provider":"Iright","version":"1.0","type":"link"}