{"product_id":"abcam-ab11434","title":"Abcam, ab11434, Anti-Ataxin 7 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nRabbit Polyclonal Ataxin 7 antibody. Suitable for WB, ICC\/IF and reacts with Transfected cell lysate, Human, African green monkey samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human ATXN7 aa 1-50.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human ATXN7 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.O15265\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAtaxin 7 also known as ATXN7 is a protein encoded by the ATXN7 gene. This protein has a molecular mass of about 104 kDa. It plays a role in transcriptional regulation and is involved in the assembly of multiprotein complexes. ATXN7 is predominantly expressed in the brain especially within regions like the cerebellum but can also be found in other tissues throughout the human body.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAtaxin 7 functions as a part of the SAGA (Spt-Ada-Gcn5 acetyltransferase) complex a multi-subunit structure that is vital for transcriptional co-activation. It helps regulate gene expression by modulating histone acetylation which in turn influences chromatin structure and accessibility. The protein interacts with various other components of the SAGA complex playing a significant role in ensuring the stability and function of the complex.\u003cbr\u003e\nPathways\u003cbr\u003e\nAtaxin 7 involves itself in the regulation of the Notch signaling pathway which is important for cellular differentiation and proliferation. This protein also plays a role in the ubiquitin-proteasome pathway which regulates protein degradation. Through these pathways Ataxin 7 is related to other proteins such as Notch receptors and ubiquitin ligases linking its function to broader cellular processes.\u003cbr\u003e\nMutations or polyglutamine expansions in the ATXN7 gene lead to spinocerebellar ataxia type 7 (SCA7) a neurodegenerative disorder characterized by progressive cerebellar ataxia and retinal degeneration. Ataxin 7 mutations may influence the aggregation of proteins like aggregates of ubiquitinated proteins which are connected to the pathology of SCA7. This highlights the role of Ataxin 7 in maintaining neural and retinal health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850165309609,"sku":"ab11434","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab11434","provider":"Iright","version":"1.0","type":"link"}