{"product_id":"abcam-ab114694","title":"Abcam, ab114694, Recombinant Human Epoxide hydrolase protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human Epoxide hydrolase protein is a Human Full Length protein, in the 1 to 455 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:SDS-PAGE, ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:P07099,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.3% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEpoxide hydrolase also known as EH or EPHX is an enzyme that catalyzes the conversion of epoxides to dihydrodiols. This reaction is important for detoxifying harmful compounds making epoxide hydrolase an important player in maintaining cellular health. The enzyme typically has a molecular mass around 53 kDa. Epoxide hydrolase is expressed in various tissues with significant activity observed in the liver where it contributes to the metabolism of xenobiotics. Alternate forms such as epoxide hydrolase 2 also exist each with specific functions and expression patterns.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe enzyme aids in the metabolic processing of xenobiotic and endogenous epoxides reducing their potential toxicity. Epoxide hydrolase operates by hydrolyzing epoxide substrates which can be harmful if accumulated. The enzyme is not part of a known permanent complex but interacts transiently with various substrates. Its biological role extends to maintaining the equilibrium between pro-inflammatory and anti-inflammatory mediators due to its influence on lipid epoxide metabolism.\u003cbr\u003e\nPathways\u003cbr\u003e\nEpoxide hydrolase plays a role in the arachidonic acid metabolic pathway where it converts epoxide intermediates into more polar diols. This action regulates the balance of eicosanoids lipid signaling molecules vital for inflammation and immune responses. The enzyme also functions alongside other detoxification enzymes such as cytochrome P450s to facilitate the biotransformation of a wide array of compounds including pharmaceutical agents.\u003cbr\u003e\nEpoxide hydrolase is linked to several conditions. Polymorphisms in the gene encoding epoxide hydrolase have associations with susceptibility to various cancers due to altered detoxification capacities. Abnormalities in enzyme activity are also associated with cardiovascular diseases as epoxide hydrolase regulates lipid mediators that modulate blood pressure and vascular tone. In these contexts the enzyme’s regulatory role intersects with proteins involved in inflammation and vascular biology like cytochrome P450s and vascular endothelial growth factor (VEGF) influencing disease progression and treatment outcomes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843899216041,"sku":"ab114694","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab114694","provider":"Iright","version":"1.0","type":"link"}