{"product_id":"abcam-ab11576","title":"Abcam, ab11576, Anti-Laminin 2 alpha antibody [4H8-2]","description":"\u003cp\u003eSize: 25µL\u003cbr\u003e\nAnti-Laminin 2 alpha antibody [4H8-2] (ab11576) is a rat monoclonal antibody detecting Laminin 2 alpha in  IHC-Fr . Suitable for  Mouse . - Clone 4H8-2 is the most cited clone to Laminin 2 alpha - Over 70 publications - Trusted since 2004\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rat,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:4H8-2,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse,\u003cbr\u003e\nApplications:IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Full Length Protein corresponding to Mouse Lama2. The exact immunogen used to generate this antibody is proprietary information.Q60675,\u003cbr\u003e\nEpitope:The epitope recognized by the antibody resides in the N-terminal portion of the alpha 2 chain of laminin.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nStorage in frost-free freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.\u003cbr\u003e\nProduct Specifications\u003cbr\u003e\nAnti-Laminin 2 alpha antibody [4H8-2] (ab11576) is a rat monoclonal antibody and is validated for use in IHC-Fr in mouse samples.\u003cbr\u003e\nAnti-Laminin 2 alpha antibody [4H8-2] (ab11576) specifically detects Laminin 2 alpha (UniProt ID: P24043; Molecular weight: 342kDa) and is sold in 25 µL selling sizes.\u003cbr\u003e\nQuality and Validation\u003cbr\u003e\nAbcam's high quality validation processes ensure Anti-Laminin 2 alpha antibody [4H8-2] (ab11576) has high sensitivity and specificity.\u003cbr\u003e\nAnti-Laminin 2 alpha antibody [4H8-2] (ab11576) has been cited over 72 times in peer reviewed journals and is trusted by the scientific community.\u003cbr\u003e\nAnti-Laminin 2 alpha antibody [4H8-2] (ab11576) has 7 independent reviews from customers.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.097% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nLaminin 2 alpha also known as laminin alpha 2 or merosin is a subunit of the laminin protein family that contributes to the structure of the extracellular matrix. It forms part of the heterotrimeric laminin 211 complex comprising alpha beta and gamma chains. Laminin 2 alpha has a molecular weight of approximately 300 kDa and is expressed in various tissues especially in skeletal muscle and the peripheral nervous system. This subunit plays an important role in anchoring cells to the basement membrane facilitating cellular adhesion and communication.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nLaminin 2 alpha contributes to the integrity and function of the basement membrane by forming a scaffold that connects cells and tissues. It is part of the greater laminin molecule which contains other laminin proteins and helps in cell differentiation migration and adhesion. The protein serves as a binding site for various integrins and dystroglycans contributing to the development and repair processes within muscular and neural systems. It ensures stability in tissue architecture maintaining proper cell signaling pathways in collaboration with other extracellular matrix components.\u003cbr\u003e\nPathways\u003cbr\u003e\nLaminin 2 alpha is involved in processes essential for tissue integrity and repair. It plays a role within the PI3K\/AKT signaling pathway which is important for cell survival and metabolism. In this pathway laminin 2 alpha of the laminin 211 complex interacts with integrins and dystroglycan complexes facilitating downstream signaling for cellular growth and differentiation. Additionally laminin 2 alpha assists in the MAPK pathway connecting with proteins like FAK which regulates cell adhesion and proliferation important for healthy tissue function and response to damage.\u003cbr\u003e\nLaminin 2 alpha is closely related to congenital muscular dystrophies particularly Merosin-deficient Congenital Muscular Dystrophy type 1A (MDC1A). This disorder is characterized by muscle weakness and developmental delays resulting from mutations in the laminin alpha 2 chain. Disruptions in laminin 2 can affect its interaction with the dystrophin-glycoprotein complex leading to compromised muscle membrane stability and tissue degeneration. Another connection exists with neuropathies where laminin 2 alpha's role in the peripheral nervous system can contribute to neural dysfunction if the protein is improperly expressed or mutated.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46844276834473,"sku":"ab11576","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab11576","provider":"Iright","version":"1.0","type":"link"}