{"product_id":"abcam-ab116807","title":"Abcam, ab116807, Recombinant Human PINCH 1 protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human PINCH 1 protein is a Human protein, in the 1 to 325 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:ELISA, SDS-PAGE, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:P48059,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.3% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product was previously labelled as LIMS1.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPINCH 1 also known as LIMS1 is a protein with a molecular mass of approximately 35 kDa. It serves an important role in cellular adhesion and signaling as part of the focal adhesion complex. Expressed widely in many tissues PINCH 1 interacts with integrin-linked kinase (ILK) and parvin proteins to mediate interactions between the extracellular matrix and the actin cytoskeleton. This interaction supports cell adhesion migration and mechanical stability critical for many cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPINCH 1 facilitates communication within cells by anchoring the cell's structural components to its signaling pathways. It forms the ternary PINCH-ILK-parvin (PIP) complex essential for transmitting mechanical and chemical signals within the cell. This complex enables cells to respond to their environments adjusting their activities accordingly. PINCH 1 also participates in the regulation of cell survival and proliferation suggesting its importance in maintaining cellular functions.\u003cbr\u003e\nPathways\u003cbr\u003e\nPINCH 1 acts as a participant in the integrin signaling and focal adhesion pathways. In these pathways PINCH 1 works alongside proteins like ILK and alpha-parvin to translate extracellular matrix signals into intracellular responses. These pathways regulate cell movement shape changes and survival by coordinating actin cytoskeleton remodeling and integrin-mediated adhesion. This coordination allows cells to adjust their behavior based on external cues.\u003cbr\u003e\nPINCH 1 has associations with cancer and cardiovascular diseases where its regulatory role in cell adhesion and signaling becomes evident. Abnormal PINCH 1 expression or function may lead to impaired cell adhesion and increased cell motility contributing to cancer metastasis. In cardiovascular diseases disruptions in PINCH 1 interactions might affect heart tissues' biomechanical integrity through pathways involving ILK. Proper PINCH 1 activity is critical for maintaining the stability and function of heart and tissue cells.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843895840937,"sku":"ab116807","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab116807","provider":"Iright","version":"1.0","type":"link"}