{"product_id":"abcam-ab117136","title":"Abcam, ab117136, Methylated DNA Immunoprecipitation (MeDIP) Kit - Tissue","description":"\u003cp\u003eSize: 24Test \/ 48Test\u003cbr\u003e\nDNA methylation is a covalent modification of the cytosine ring at the 5' position of a CpG dinucleotide which leads to epigenetic inactivation of genes when found in 5'-CpG-3'dinucleotides within promoters or in the first exon of genes.\u003cbr\u003e\nKey facts\u003cbr\u003e\nAssay time:3h 30m,\u003cbr\u003e\nSample types:Tissue,\u003cbr\u003e\nReacts with:Mouse, Human\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nDNA methylation is a covalent modification of the cytosine ring at the 5' position of a CpG dinucleotide which leads to epigenetic inactivation of genes when found in 5'-CpG-3'dinucleotides within promoters or in the first exon of genes. It has been demonstrated that DNA methylation plays an important role in the regulation of gene expression, tumorigenesis, and other genetic and epigenetic diseases, and that alterations in DNA methylation patterns are associated with cancer.\u003cbr\u003e\nMethylated DNA Immunoprecipitation (MeDIP) ChIP Kit (ab117136) enables the user to enrich\u003cbr\u003e\nmethylated DNA directly from various mammalian tissues\u003cbr\u003e\nby using an antibody specific to methyl cytosine (5-mC) to immunoprecipitate methylated genomic DNA\u003cbr\u003e\n(MeDIP)\u003cbr\u003e\n. The enriched methylated fractions can then be used in various downstream applications including qualitative and quantitative PCR, as well as southern blot and DNA microarray.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-+4°C\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847697223849,"sku":"ab117136","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab117136","provider":"Iright","version":"1.0","type":"link"}