{"product_id":"abcam-ab118470","title":"Abcam, ab118470, Anti-e-LOX-3 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal e-LOX-3 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Hydroperoxide isomerase ALOXE3.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human Hydroperoxide isomerase ALOXE3. The exact immunogen used to generate this antibody is proprietary information.Q9BYJ1\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Lyophilized, Reconstitution-Reconstitute in 200 µL of water, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe e-LOX-3 also known as Epidermis-type Lipoxygenase 3 is an enzyme that plays a role in the lipoxygenase family. It has an estimated mass of approximately 75 kDa. Researchers find e-LOX-3 expressed in human skin playing a role in the epidermal layer. This enzyme participates in the process of oxidation of polyunsaturated fatty acids. It influences the formation of certain signaling molecules and lipid peroxidation products in the body.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMutations affecting e-LOX-3 disrupt important epidermal barrier functions. e-LOX-3 acts as a component of the complex lipoxygenase pathway involved in metabolizing fatty acids into oxygenated products. This pathway is important for maintaining skin health and homeostasis by contributing to the development and maintenance of the epidermal lipid barrier. e-LOX-3 helps create metabolites that act as signaling molecules in skin differentiation and function.\u003cbr\u003e\nPathways\u003cbr\u003e\nE-LOX-3 is an important element in the arachidonic acid pathway and the related lipoxygenase pathway. Lipoxygenase enzymes such as 12-LOX and 15-LOX interact with e-LOX-3 in producing bioactive lipids essential for skin health. The enzyme plays a role in converting polyunsaturated fatty acids into hydroxy fatty acids or hydroperoxy derivatives which serve critical functions in inflammation and repair processes within the skin.\u003cbr\u003e\nAlterations in e-LOX-3 function link to ichthyosis and psoriasis. e-LOX-3 mutations can cause non-bullous congenital ichthyosiform erythroderma (NCIE) characterized by scaly skin due to disrupted lipid metabolism. Its activity impacts other proteins like transglutaminase 1 which is critical in maintaining skin barrier function. Understanding the role of e-LOX-3 in skin conditions provides potential therapeutic targets for treatment strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854353551529,"sku":"ab118470","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab118470","provider":"Iright","version":"1.0","type":"link"}