{"product_id":"abcam-ab11873","title":"Abcam, ab11873, Anti-C3a \/ C3a des Arg antibody [2991]","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Monoclonal C3 antibody. Suitable for WB and reacts with Human samples. Cited in 5 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:2991,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nSpecificity:ab11873 reacts with a neo-epitope (des-Arg) on C3a that is formed when C3 is cleaved into C3a and C3b. ab11873 recognizes C3a and C3a des arg only. It has the most affinity with C3a des arg and least affinity with C3a. The des arg variant has an about 5x higher affinity than C3a. The antibody does not recognize C3b or full C3, as it recognizes a neo-epitope that is not available on C3.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Purification notes-0.2 µm filtered, Storage buffer-Preservative: 0.02% Sodium azideConstituents: PBS, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nC3a also known as C3a des Arg or C3a full form is a small peptide anaphylatoxin derived from the complement component C3. It plays an important mechanical role in the immune system by acting as a potent mediator of inflammation. C3a weighs approximately 9 kDa. It expresses primarily on the surface of immune cells such as mast cells and basophils. The function of C3a involves the binding to the C3a receptor (C3aR) triggering a series of immune responses.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nC3a serves as an essential inflammatory agent and is part of the complement system an important component of the innate immune response. It contributes to the defense against pathogens by promoting chemotaxis degranulation and the release of histamine. C3a desArg a derivative of C3a generated by the removal of the C-terminal arginine residue has reduced inflammatory activity. The activity of C3a and its link to inflammation highlights its importance in maintaining immune homeostasis and responding to infectious threats.\u003cbr\u003e\nPathways\u003cbr\u003e\nC3a plays an important role in the complement activation cascade particularly the classical and alternative pathways. This involvement highlights its relationship with proteins such as C3b and C5 which are critical in the opsonization and membrane attack complex formation. C3a's role in these pathways accentuates its importance in modulating inflammation and immune response.\u003cbr\u003e\nAbnormalities in C3a regulation have notable implications. C3a is associated with various inflammatory and autoimmune diseases like asthma and rheumatoid arthritis. In asthma C3a interacts with other complement proteins such as C5a to exacerbate inflammation in the airways. Dysregulation of C3a and its conversion to C3a desArg may further contribute to pathologies implicating its potential as a therapeutic target in managing inflammatory diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854697156777,"sku":"ab11873","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab11873","provider":"Iright","version":"1.0","type":"link"}