{"product_id":"abcam-ab119269","title":"Abcam, ab119269, Anti-GATM antibody [OTI1C9]","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nMouse Monoclonal GATM antibody. Suitable for WB, IHC-P, ICC\/IF, Flow Cyt (Intra) and reacts with Human, Transfected cell lysate - Human, Transfected cell line - Human, Transfected cell line samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human GATM.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:OTI1C9,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, Flow Cyt (Intra), IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human GATM.P50440\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Purification notes-Purified from cell culture supernatant by affinity chromatography., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGATM also known as glycine amidinotransferase or L-arginine:glycine amidinotransferase functions as an enzyme responsible for the catalysis of the first step in creatine biosynthesis. This enzyme has a molecular mass of approximately 49 kDa. GATM is mostly expressed in the kidney pancreas and liver. In these tissues it catalyzes the transfer of an amidino group from L-arginine to glycine forming guanidinoacetate the immediate precursor for creatine.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGlycine amidinotransferase participates in important metabolic processes by forming guanidinoacetate. This compound collaborates with S-adenosylmethionine to eventually form creatine an important molecule important for storing and distributing energy in cells. GATM does not function as part of a larger complex; it works independently to perform its enzymatic reaction. Its biological activity directly impacts muscle function and also affects organ systems that depend on energy homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nGATM plays a significant role in creatine synthesis connecting to the energy metabolism pathway. The creatine biosynthesis pathway begins with GATM's production of guanidinoacetate and concludes with the formation of creatine after a conversion facilitated by the enzyme GAMT (guanidinoacetate N-methyltransferase). GATM functions as an upstream regulator impacting ATP supply in tissues where high-energy demands occur like in muscle cells.\u003cbr\u003e\nResearchers associate GATM with conditions related to energy metabolism deficiencies such as certain myopathies and guanidinoacetate methyltransferase deficiency. These conditions arise when alterations in creatine synthesis disrupt normal cellular energy dynamics. GATM mutations can affect overall energy availability leading to muscle and neurological symptoms. The enzyme GAMT interacts with GATM within these metabolic contexts illustrating a close connection in the pathology of related disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854630703273,"sku":"ab119269","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab119269","provider":"Iright","version":"1.0","type":"link"}