{"product_id":"abcam-ab119800","title":"Abcam, ab119800, Anti-GOLPH2 antibody [OTI6C9]","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nMouse Monoclonal GOLPH2 antibody. Suitable for WB, IHC-P, ICC\/IF, Flow Cyt (Intra) and reacts with Human, Transfected cell lysate - Human, African green monkey, Transfected cell line - Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human GOLM1.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:OTI6C9,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, African green monkey,\u003cbr\u003e\nApplications:IHC-P, Flow Cyt (Intra), WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human GOLM1.Q8NBJ4\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThe clone number has been updated from 6C9 to OTI6C9, both clone numbers name the same clone.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Purification notes-Purified from cell culture supernatant by affinity chromatography., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGOLPH2 also known as GOLM1 or Golgi membrane protein 1 has a significant mechanical role in the cell. It is a 73-kilodalton protein found mainly in the Golgi apparatus. This protein gets expressed in various tissues with notable levels in the liver and other organs involved in secretion. It acts as a transmembrane protein in the Golgi where it helps in processing and sorting secretory proteins influencing how proteins move through secretory pathways.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGOLPH2 plays an essential role in maintaining Golgi function and efficient protein trafficking. It does not belong to a large protein complex but its proper functioning is critical for handling secretory pathways. The protein keeps secretory flow organized which affects cellular responses and interactions with the environment. The GOLPH2 protein also has connections to immunity responding to stimuli like infections or inflammation.\u003cbr\u003e\nPathways\u003cbr\u003e\nGOLPH2 actively participates in secretory pathways and protein transport systems. Its role includes coordination with other Golgi proteins to facilitate protein modification and sorting. GOLPH2 interacts with other proteins like GOLM1 and GOLPH3 impacting the Golgi's structural organization and influencing pathways like vesicular transport. These interactions are important for adapting the intracellular environment to external demands.\u003cbr\u003e\nGOLPH2 levels change in diseases such as liver cancer and hepatitis. These changes can serve as biomarkers for diagnosis and disease progression monitoring. GOLPH2 also connects with proteins involved in these diseases including AFP a known tumor marker. Understanding GOLPH2's role in such conditions aids research in developing diagnostic tools and therapeutic strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854645645481,"sku":"ab119800","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab119800","provider":"Iright","version":"1.0","type":"link"}