{"product_id":"abcam-ab119802","title":"Abcam, ab119802, Anti-NLN antibody [OTI1D6]","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nMouse Monoclonal NLN antibody. Suitable for WB, IHC-P, ICC\/IF, Flow Cyt (Intra) and reacts with Mouse, Rat, Transfected cell lysate - Human, Human, African green monkey, Transfected cell line - Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human NLN.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:OTI1D6,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human, African green monkey,\u003cbr\u003e\nApplications:ICC\/IF, Flow Cyt (Intra), WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human NLN.Q9BYT8\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThe clone number has been updated from 1D6 to OTI1D6, both clone numbers name the same clone.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification, Purification notes-Purified from cell culture supernatant by affinity chromatography., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNLN also known as Neurolysin is a 77 kDa metalloendopeptidase enzyme with an ability to cleave neuropeptides at specific sites. Researchers frequently observe NLN in the central nervous system kidneys testis and muscle tissues. This enzyme notably exists as a mitochondrial matrix protein showing an evolutionary conservation in its structure across mammalian species. NLN plays a role in processing bioactive peptides displaying similarity in substrate specificity to its better-known counterpart thimet oligopeptidase.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNLN degrades neuropeptides which aids in regulating their activity and maintaining homeostasis. It does not typically form part of a large complex but interacts directly with peptide substrates to exert its effects. By modulating peptide availability NLN influences neurological functions and potentially affects signaling pathways involved in mood pain and energy regulation. Researchers continue to explore NLN's physiological roles and interactions though its exact contributions outside peptide processing remain less detailed.\u003cbr\u003e\nPathways\u003cbr\u003e\nStudies show NLN engages in the metabolism of bioactive peptides including enkephalins and tachykinins. In these pathways NLN acts to terminate peptide signaling by cleaving them which alters receptor interactions. Within these mechanisms NLN shares activity with proteins like neprilysin both contributing to peptide degradation but acting on different substrates or within distinct cellular locales. These pathways are critical for maintaining neural function and homeostasis underlying many processes in the nervous system.\u003cbr\u003e\nDysregulation of NLN activity links to conditions such as hypertension and Alzheimer's disease. In hypertension improper peptide degradation can affect blood pressure regulation. In Alzheimer’s disease NLN’s inability to regulate amyloid-beta peptides in association with neprilysin contributes to plaque accumulation a hallmark of the disease. Understanding NLN’s role offers potential therapeutic insights for correcting peptide imbalances related to these disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854729695401,"sku":"ab119802","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab119802","provider":"Iright","version":"1.0","type":"link"}