{"product_id":"abcam-ab120003","title":"Abcam, ab120003, D-AP5, NMDA glutamate site antagonist","description":"\u003cp\u003eSize: 1mg \/ 10mg \/ 50mg \/ 100mg\u003cbr\u003e\nCompetitive NMDA receptor glutamate site antagonist. More active form of DL-AP5. 2-APV,D-APV,D-2-amino-5-phosphonovalerate. MW 197.1. - Available in different sizes to fit your experimental needs\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:79055-68-8,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:197.13 Da,\u003cbr\u003e\nMolecular formula:C5H12NO5P,\u003cbr\u003e\nPubChem:135342,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Available in multiple formats – ab144482: Soluble in 1 ml of water to give specified mM\/ml concentration; ab120003: Soluble in water to 100 mM; ab285210: Supplied,\u003cbr\u003e\nBiochemical name:5-Phosphono-D-norvaline,\u003cbr\u003e\nBiological description:Competitive NMDA receptor glutamate site antagonist. More active form of DL-AP5.,\u003cbr\u003e\nCanonical smiles:C(CC(C(=O)O)N)CP(=O)(O)O,\u003cbr\u003e\nIsomeric smiles:C(C[C@H](C(=O)O)N)CP(=O)(O)O,\u003cbr\u003e\nInChi:InChI=1S\/C5H12NO5P\/c6-4(5(7)8)2-1-3-12(9,10)11\/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)\/t4-\/m1\/s1,\u003cbr\u003e\nInChiKey:VOROEQBFPPIACJ-SCSAIBSYSA-N,\u003cbr\u003e\nIUPAC Name:(2R)-2-amino-5-phosphonopentanoic acid\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nCheck out our range of NMDA glutamate antagonist\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNMDAR and AMPA receptors have massive implications in neurodegenerative diseases like Alzheimer's and neuropsychiatric disorders such as schizophrenia. Dysregulation in NMDAR function possibly through inadequate blockade by antagonists like D-AP5 or D-APV links to excitotoxicity a condition contributing to neuronal death as seen in Alzheimer's. In schizophrenia altered NMDAR signaling is connected to cognitive dysfunction and both NMDAR and AMPA may serve as therapeutic targets.\u003cbr\u003e\nPathways\u003cbr\u003e\nNMDARs and AMPA receptors integrate into key neural and signaling pathways such as the long-term potentiation pathway which is essential for memory formation. NMDAR activation allows calcium influx necessary for initiating intracellular signaling cascades. The interactions with proteins like CaMKII and synaptic scaffolds like PSD-95 illustrate the role of these receptors in synaptic and protein signaling networks that adjust synaptic strength.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThese glutamate receptor subunits forming part of NMDAR and AMPA receptor complexes modulate synaptic plasticity which underlies learning and memory. NMDARs are tetrameric complexes composed mostly of two GluN1 subunits combined with two region-specific GluN2 (A-D) or GluN3 (A B) subunits creating diversity in function and pharmacological characteristics. The AMPA receptor primarily built of GluA1 through GluA4 subunits contributes to fast excitatory neurotransmission. Together these receptors regulate calcium ion flow into neurons impacting cellular events essential for neural communication and adaptation.\u003cbr\u003e\nThe N-Methyl-D-Aspartate Receptor (NMDAR) subunits such as NMDAR2A NMDAR2B GluN2C NMDAR1 GluN2D NR3A and NR3B are key components of glutamate receptors also including the AMPA subtype Glutamate Receptor 1. These receptors are ionotropic and mediate synaptic transmission in the central nervous system. They are expressed in the brain particularly in regions such as the hippocampus and cortex. NMDAR1 also known as GluN1 serves as an obligatory subunit required for functional receptor assembly. The mass of NMDAR subunits varies; for example the GluN1 subunit has an approximate mass of 120 kDa.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847395463337,"sku":"ab120003","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab120003","provider":"Iright","version":"1.0","type":"link"}