{"product_id":"abcam-ab120005","title":"Abcam, ab120005, (S)-AMPA, agonist","description":"\u003cp\u003eSize: 5mg \/ 10mg \/ 50mg\u003cbr\u003e\nMW 186.17 Da, Purity \u0026gt;98%. AMPA agonist. Achieve your results faster with highly validated, pure and trusted compounds.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:83643-88-3,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:186.17 Da,\u003cbr\u003e\nMolecular formula:C7H10N2O4,\u003cbr\u003e\nPubChem:158397,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nBiochemical name:(S)-Ampa,\u003cbr\u003e\nBiological description:AMPA agonist.,\u003cbr\u003e\nCanonical smiles:CC1=C(C(=O)NO1)CC(C(=O)O)N,\u003cbr\u003e\nIsomeric smiles:CC1=C(C(=O)NO1)C[C@@H](C(=O)O)N,\u003cbr\u003e\nInChi:InChI=1S\/C7H10N2O4\/c1-3-4(6(10)9-13-3)2-5(8)7(11)12\/h5H,2,8H2,1H3,(H,9,10)(H,11,12)\/t5-\/m0\/s1,\u003cbr\u003e\nInChiKey:UUDAMDVQRQNNHZ-YFKPBYRVSA-N,\u003cbr\u003e\nIUPAC Name:(2S)-2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGlutamate Receptor 1 also known as AMPA receptor or GluA1 is an ionotropic receptor for glutamate the chief excitatory neurotransmitter in the central nervous system. Other alternate names include Glutamate Receptor 2 (GluA2) Glutamate receptor 3 (GluA3) GluK5 GluK1 and GluA4. These subtypes have similar structures but vary in their distribution and function. The mass of this receptor is not explicitly detailed as it forms tetrameric complexes. These receptors are expressed widely across the brain particularly in the postsynaptic sites of neurons where they play key roles in synaptic transmission.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe AMPA receptor facilitates fast synaptic transmission and is involved in synaptic plasticity which is important for learning and memory. These receptors form a heteromeric complex often consisting of different subunits like GluA1 GluA2 GluA3 and GluA4. The receptor mechanism involves the binding of glutamate which leads to the opening of the ion channel. This allows the flow of sodium (Na+) and to a lesser extent calcium (Ca2+) contributing to the excitatory postsynaptic potential in neurons.\u003cbr\u003e\nPathways\u003cbr\u003e\nThese ionotropic glutamate receptors function in the glutamatergic signaling pathway and the long-term potentiation pathway. They pair with proteins such as NMDA receptors and various scaffolding proteins within synaptic complexes. These pathways regulate synaptic strength and are critical for cognitive processes like learning. Indeed the balance and modulation of GluA and associated proteins are essential for normal neuronal communication and plasticity.\u003cbr\u003e\nThe AMPA receptors are associated with neurological conditions such as epilepsy and neurodegenerative diseases like Alzheimer’s disease. Aberrant activity or expression levels of AMPA receptor subunits can lead to excitotoxicity which is damage caused by excessive stimulation by neurotransmitters such as glutamate. In these contexts AMPA antagonists may offer therapeutic potential. These receptors also connect to tau proteins in the context of Alzheimer's disease highlighting their role in the pathology associated with neurodegeneration.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847404376233,"sku":"ab120005","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab120005","provider":"Iright","version":"1.0","type":"link"}