{"product_id":"abcam-ab120012","title":"Abcam, ab120012, CGP 37157, Na+-Ca2+ exchange inhibitor","description":"\u003cp\u003eSize: 10mg \/ 50mg\u003cbr\u003e\nMW 324.2 Da, Purity \u0026gt;99%. Selective inhibitor of the mitochondrial Na+-Ca2+ exchanger (IC50 = 0.4 μM). Achieve your results faster with highly validated, pure and trusted compounds.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:75450-34-9,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:324.2 Da,\u003cbr\u003e\nMolecular formula:C15H11Cl2NOS,\u003cbr\u003e\nPubChem:2688,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in water to 5 mMSoluble in ethanol to 100 mMSoluble in DMSO to 100 mM,\u003cbr\u003e\nBiochemical name:7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one,\u003cbr\u003e\nBiological description:Selective inhibitor of the mitochondrial Na+-Ca2+ exchanger (IC50 = 0.4 μM).,\u003cbr\u003e\nCanonical smiles:C1C(=O)NC2=C(C=C(C=C2)Cl)C(S1)C3=CC=CC=C3Cl,\u003cbr\u003e\nInChi:InChI=1S\/C15H11Cl2NOS\/c16-9-5-6-13-11(7-9)15(20-8-14(19)18-13)10-3-1-2-4-12(10)17\/h1-7,15H,8H2,(H,18,19),\u003cbr\u003e\nInChiKey:KQEPIRKXSUIUTH-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:7-chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2-one\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSLC24A6 also known as the sodium\/potassium\/calcium exchanger 6 or NCKX6 is a membrane protein involved in the exchange of ions. This protein enables the transport of Na+ Ca2+ and K+ ions across cellular membranes. Its molecular mass is approximately 73 kDa. SLC24A6 is expressed in several tissues particularly in the brain where its function is important for maintaining ion balance within neuronal cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThere are important roles that SLC24A6 plays in cellular homeostasis and signal transduction. As part of a complex network of ion transporters SLC24A6 aids in regulating calcium ion concentration within cells. This regulation is essential for neuronal signaling and overall cellular communication. The ability to exchange ions efficiently allows cells to respond accurately to physiological changes.\u003cbr\u003e\nPathways\u003cbr\u003e\nSLC24A6 is involved in important signaling cascades such as the calcium signaling pathway and calcineurin signaling pathway. In the calcium signaling pathway it helps modulate intracellular calcium levels which influence various cellular processes like muscle contraction and neurotransmitter release. SLC24A6 also interacts with other ion exchangers and transporters playing a role alongside proteins such as calmodulin which further affect neuronal function.\u003cbr\u003e\nSLC24A6 has been associated with conditions like bipolar disorder and schizophrenia. Studies suggest that dysfunction in ion homeostasis due to altered SLC24A6 activity can lead to these neurological disorders. Proteins such as DISC1 implicated in multiple mental health conditions are also connected to dysregulation observed in these diseases highlighting the involvement of SLC24A6 within complex genetic and biochemical networks contributing to mental health disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847418335401,"sku":"ab120012","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab120012","provider":"Iright","version":"1.0","type":"link"}