{"product_id":"abcam-ab120052","title":"Abcam, ab120052, NMDA, excitotoxic amino acid","description":"\u003cp\u003eSize: 50mg \/ 100mg \/ 500mg\u003cbr\u003e\nMW 147.13 Da, Purity \u0026gt;99%. Excitotoxic amino acid. Prototypic agonist at the ionotropic NMDA glutamate receptor which is involved in long-term potentiation, ischemia, and epilepsy.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:6384-92-5,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:147.13 Da,\u003cbr\u003e\nMolecular formula:C5H9NO4,\u003cbr\u003e\nPubChem:22880,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nBiochemical name:N-methyl-D-aspartic acid,\u003cbr\u003e\nBiological description:Excitotoxic amino acid. Prototypic agonist at the ionotropic NMDA glutamate receptor which is involved in long-term potentiation, ischemia, and epilepsy.,\u003cbr\u003e\nCanonical smiles:CNC(CC(=O)O)C(=O)O,\u003cbr\u003e\nIsomeric smiles:CN[C@H](CC(=O)O)C(=O)O,\u003cbr\u003e\nInChi:InChI=1S\/C5H9NO4\/c1-6-3(5(9)10)2-4(7)8\/h3,6H,2H2,1H3,(H,7,8)(H,9,10)\/t3-\/m1\/s1,\u003cbr\u003e\nInChiKey:HOKKHZGPKSLGJE-GSVOUGTGSA-N,\u003cbr\u003e\nIUPAC Name:(2R)-2-(methylamino)butanedioic acid\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe target proteins NMDAR2A NMDAR2B GluN2C NMDAR1 TSH Receptor\/TSH-R and Glutamate Receptor 1 (AMPA subtype) play key roles within the central nervous system and endocrine system. NMDAR2A NMDAR2B and GluN2C are subunits of NMDAR a glutamate receptor and ion channel. These subunits contribute to the receptor's structure and function facilitating synaptic transmission and plasticity. NMDAR molecules generally have high molecular weights due to their complex structure. NMDARs are widely expressed in the brain particularly in the hippocampus and cortex. The TSH Receptor (TSH-R) found in the thyroid gland mediates thyroid-stimulating hormone activity important for thyroid hormone production regulation. Glutamate Receptor 1 (AMPA subtype) is an ionotropic receptor that also facilitates synaptic transmission throughout the CNS.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThese proteins participate in neurotransmission and signal transduction. NMDARs form part of a receptor complex interacting with various regulatory proteins facilitating calcium ion influx when activated by glutamate. This ion movement is essential for long-term potentiation and synaptic plasticity important for learning and memory. The TSH receptor functions in the thyroid hormone synthesis signaling pathway initiating cascades upon thyroid stimulating hormone binding. Meanwhile AMPA receptors mediate fast synaptic transmission primarily through sodium ion flux contributing significantly to excitatory neurotransmission in the brain.\u003cbr\u003e\nPathways\u003cbr\u003e\nNMDARs are central to the glutamatergic pathway involving neurotransmitter release and various intracellular signaling mechanisms. This pathway intersects with the calcium\/calmodulin-dependent protein kinase (CaMK) pathway. Proteins such as CaMKII associate with NMDARs impacting synaptic strength and excitability. The TSH receptor operates within the hypothalamic-pituitary-thyroid (HPT) axis influencing thyroid hormone levels. This receptor collaborates with other proteins like G-proteins to propagate intracellular signaling. AMPA receptors interact with NMDA receptors in synaptic transmission pathways influencing neuronal communication and plasticity.\u003cbr\u003e\nNMDAR dysfunction is associated with neurological disorders such as Alzheimer's disease and schizophrenia. Alterations in synaptic plasticity linked to these receptors affect memory and cognition. The TSH receptor through its role in the thyroid hormone pathway is connected to disorders such as Graves' disease and thyroid cancer. The autoantibodies against TSH receptors play a pivotal role in disease pathology affecting thyroid function. AMPA receptor dysregulation can contribute to neurodegenerative diseases where excitotoxicity plays an important role affecting neuronal survival.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847402868905,"sku":"ab120052","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab120052","provider":"Iright","version":"1.0","type":"link"}