{"product_id":"abcam-ab120468","title":"Abcam, ab120468, Dynamin Inhibitors Toolbox","description":"\u003cp\u003eSize: 1Kit\u003cbr\u003e\nDynamin Inhibitors Toolbox (ab120468) is part of the multiplex kits range. Abcam offers high-quality biological reagents and tools including antibodies, proteins, assays, cell lines and lysates.\u003cbr\u003e\nKey facts\u003cbr\u003e\nApplications:FuncSSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThe Dynamin Inhibitors Toolbox (ab120468) is a unique collection of small molecule, potent, and cell permeable dynamin inhibitors, enabling characterization of dynamin and endocytosis. The inhibitors have different mechanisms of action, target different domains of dynamin, and are based on differing chemical scaffolds.\u003cbr\u003e\nNegative controls for each chemical series are included.\u003cbr\u003e\nThe Toolbox contains 1mg of each of the following: MiTMAB™ (\u003cbr\u003e\nab120466\u003cbr\u003e\n), OcTMAB™ (\u003cbr\u003e\nab120467\u003cbr\u003e\n), Pro-Mystyric Acid (\u003cbr\u003e\nab120476\u003cbr\u003e\n), Dynole-34-2™ (\u003cbr\u003e\nab120463\u003cbr\u003e\n) and Dynole-31-2™ (\u003cbr\u003e\nab120464\u003cbr\u003e\nMiTMAB\u003cbr\u003e\nchemical series collection\u003cbr\u003e\nContains MiTMAB\u003cbr\u003e\nab120466\u003cbr\u003e\n), OcTMAB\u003cbr\u003e\nab120467\u003cbr\u003e\n) and Pro-Myristic Acid (\u003cbr\u003e\nab120476\u003cbr\u003e\n). OcTMAB\u003cbr\u003e\nand MiTMAB\u003cbr\u003e\ntarget dynamin at the lipid binding (PH) domain and inhibit dynamin and endocytosis in enzymatic and cell based assays. They are based on the same chemical scaffold.\u003cbr\u003e\nPro-Myristic acid is an in vitro inhibitor of dynamin. Although cell permeable, it is rapidly broken down by cellular esterases to release intracellular myristic acid, which is not a dynamin inhibitor. It can therefore be used as a negative control in cell-based studies.\u003cbr\u003e\nDynole\u003cbr\u003e\nchemical series collection\u003cbr\u003e\nContains dynamin inhibitor Dynole-34-2\u003cbr\u003e\nab120463\u003cbr\u003e\n) and negative control Dynole-31\u003cbr\u003e\nab120464\u003cbr\u003e\n) from the Dynole chemical series. Dynole-34-2\u003cbr\u003e\ntargets dynamin at the GTPase Allosteric Site (GAS) domain and inhibits dynamin and endocytosis in enzymatic and cell based assays. The inhibitor and negative control are based on the same chemical scaffold.\u003cbr\u003e\nPH lipid binding site\u003cbr\u003e\nMiTMAB™ -\u003cbr\u003e\nCell-permeable dynamin I and dynamin II inhibitor\u003cbr\u003e\nPH lipid binding site\u003cbr\u003e\nOcTMAB™ -\u003cbr\u003e\nCell permeable dynamin I and dynamin II inhibitor\u003cbr\u003e\nPH lipid binding site\u003cbr\u003e\nPro-Myristic Acid -\u003cbr\u003e\nNegative control for MiTMAB™ and OcTMAB™\u003cbr\u003e\nGTPase Allosteric Site\u003cbr\u003e\nDynole-34-2™ -\u003cbr\u003e\nPotent dynamin I and dynamin II inhibitor\u003cbr\u003e\nGTPase Allosteric Site\u003cbr\u003e\nDynole-31-2™ -\u003cbr\u003e\nNegative control for Dynole 34-2™\u003cbr\u003e\nProviding storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.\u003cbr\u003e\nWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.\u003cbr\u003e\nSold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. Dynole-34-2™, Dynole-31-2™, MiTMAB™ and OcTMAB™ are trademarks of Children's Medical Research Institute and Newcastle Innovation Ltd.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-+4°C\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847586893993,"sku":"ab120468","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab120468","provider":"Iright","version":"1.0","type":"link"}