{"product_id":"abcam-ab120637","title":"Abcam, ab120637, KU-55933, competitive ATM kinase inhibitor","description":"\u003cp\u003eSize: 10mg\u003cbr\u003e\nMW 395.5 Da, Purity \u0026gt;99%. Potent, selective and competitive ATM kinase inhibitor. IC 50  values are 12.9 (ATM), 2000 (DNA-PK), 9300 (mTOR), 16600 (PI3K), \u0026gt;100000 (ATR) and \u0026gt;100000 nM (PI4K). Sensitizes cells to ionizing radiation and chemotherapeutics. Blocks Akt phosphorylation, induces G1 cell cycle arrest and induces apoptosis in breast and prostate cell lines.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:587871-26-9,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:395.5 Da,\u003cbr\u003e\nMolecular formula:C21H17NO3S2,\u003cbr\u003e\nPubChem:5278396,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 100 mMSoluble in ethanol to 50 mM,\u003cbr\u003e\nBiochemical name:2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-one,\u003cbr\u003e\nBiological description:Potent, selective and competitive ATM kinase inhibitor. IC50 values are 12.9 (ATM), 2000 (DNA-PK), 9300 (mTOR), 16600 (PI3K), \u0026gt;100000 (ATR) and \u0026gt;100000 nM (PI4K). Sensitizes cells to ionizing radiation and chemotherapeutics. Blocks Akt phosphorylation, induces G1 cell cycle arrest and induces apoptosis in breast and prostate cell lines.,\u003cbr\u003e\nCanonical smiles:C1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4,\u003cbr\u003e\nInChi:InChI=1S\/C21H17NO3S2\/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19\/h1-7,12-13H,8-11H2,\u003cbr\u003e\nInChiKey:XRKYMMUGXMWDAO-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:2-morpholin-4-yl-6-thianthren-1-ylpyran-4-one\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847403327657,"sku":"ab120637","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab120637","provider":"Iright","version":"1.0","type":"link"}