{"product_id":"abcam-ab120648","title":"Abcam, ab120648, SB 328437, CCR3 antagonist","description":"\u003cp\u003eSize: 10mg \/ 50mg\u003cbr\u003e\nMW 378.4 Da, Purity \u0026gt;99%. A highly potent and selective CC chemokine receptor-3 (CCR3) antagonist (IC 50  = 4 nM). Shows \u0026gt;2500-fold selectivity over CCR7, CXCR1, CXCR2, C4aR and LTD 4  receptors. Inhibits Ca 2+  mobilization induced by eotaxin, eotaxin-2 and MCP-4 (IC 50  values are 38, 35, and 20 nM, respectively). Also inhibits eosinophil chemotaxis.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:247580-43-4,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:378.4 Da,\u003cbr\u003e\nMolecular formula:C21H18N2O5,\u003cbr\u003e\nPubChem:10474776,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 100 mM,\u003cbr\u003e\nBiochemical name:methyl (2S)-2-(naphthalene-2-carbonylamino)-3-(4-nitrophenyl)propanoate,\u003cbr\u003e\nBiological description:A highly potent and selective CC chemokine receptor-3 (CCR3) antagonist (IC50 = 4 nM). Shows \u0026gt;2500-fold selectivity over CCR7, CXCR1, CXCR2, C4aR and LTD4 receptors. Inhibits Ca2+ mobilization induced by eotaxin, eotaxin-2 and MCP-4 (IC50 values are 38, 35, and 20 nM, respectively). Also inhibits eosinophil chemotaxis.,\u003cbr\u003e\nCanonical smiles:COC(=O)C(CC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C2=CC=CC3=CC=CC=C32,\u003cbr\u003e\nIsomeric smiles:COC(=O)[C@H](CC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C2=CC=CC3=CC=CC=C32,\u003cbr\u003e\nInChi:InChI=1S\/C21H18N2O5\/c1-28-21(25)19(13-14-9-11-16(12-10-14)23(26)27)22-20(24)18-8-4-6-15-5-2-3-7-17(15)18\/h2-12,19H,13H2,1H3,(H,22,24)\/t19-\/m0\/s1,\u003cbr\u003e\nInChiKey:VMFGCGRAIBLAFY-IBGZPJMESA-N,\u003cbr\u003e\nIUPAC Name:methyl (2S)-2-(naphthalene-1-carbonylamino)-3-(4-nitrophenyl)propanoate\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847426068649,"sku":"ab120648","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab120648","provider":"Iright","version":"1.0","type":"link"}