{"product_id":"abcam-ab120687","title":"Abcam, ab120687, Pitstop® 2, Novel cell-permeable clathrin inhibitor","description":"\u003cp\u003eSize: 5mg\u003cbr\u003e\nNovel, selective, cell membrane permeable clathrin inhibitor. Competitively inhibits clathrin terminal domain to selectively inhibit clathrin mediated endocytosis (CME) (IC 50  = 12 µM for inhibition of amphiphysin association of clathrin TD). - 15µM of ab120687 sufficient to block compensatory endocytosis of neuronal presynaptic compartments.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:473.4 Da,\u003cbr\u003e\nMolecular formula:C20H13BrN2O3S2,\u003cbr\u003e\nPubChem:137254289,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO. Please refer to the Protocol Booklet for more information.,\u003cbr\u003e\nBiochemical name:2-(1-Naphthylsulfonylamino)-5-[(Z)-4-bromobenzylidene]-2-thiazoline-4-one,\u003cbr\u003e\nBiological description:Novel, selective, cell membrane permeable clathrin inhibitor. Competitively inhibits clathrin terminal domain to selectively inhibit clathrin mediated endocytosis (CME) (IC50 = 12 μM for inhibition of amphiphysin association of clathrin TD). Interferes with receptor mediated endocytosis (RME), entry of HIV and synaptic vesicle recycling.,\u003cbr\u003e\nCanonical smiles:C1=CC=C2C(=C1)C=CC=C2S(=O)(=O)N=C3NC(=O)C(=CC4=CC=C(C=C4)Br)S3,\u003cbr\u003e\nIsomeric smiles:C1=CC=C2C(=C1)C=CC=C2S(=O)(=O)N=C3NC(=O)\/C(=C\/C4=CC=C(C=C4)Br)\/S3,\u003cbr\u003e\nInChi:InChI=1S\/C20H13BrN2O3S2\/c21-15-10-8-13(9-11-15)12-17-19(24)22-20(27-17)23-28(25,26)18-7-3-5-14-4-1-2-6-16(14)18\/h1-12H,(H,22,23,24)\/b17-12-,\u003cbr\u003e\nInChiKey:CGDLWHGPJPVPDU-ATVHPVEESA-N,\u003cbr\u003e\nIUPAC Name:N-[(5Z)-5-[(4-bromophenyl)methylidene]-4-oxo-1,3-thiazolidin-2-ylidene]naphthalene-1-sulfonamide\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nHigh concentrations of Pitstop ™ may interfere with fluorescence imaging due to a low emittance of the compound in the green channel. This fluorescence is not usually detectable if the cells have been first fixed and washed prior to imaging.\u003cbr\u003e\nCheck out our range of clathrin inhibitors\u003cbr\u003e\nSold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. Pitstop® is a trademark of Freie Universitat Berlin, Newcastle Innovation Ltd. and Children's Medical Research Institute.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847395856553,"sku":"ab120687","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab120687","provider":"Iright","version":"1.0","type":"link"}