{"product_id":"abcam-ab120689","title":"Abcam, ab120689, Dyngo® 4a highly potent dynamin inhibitor","description":"\u003cp\u003eSize: 5mg\u003cbr\u003e\nDyngo ®  4a highly potent cell permeable dynamin inhibitor (IC50 values are 400 nM and 200 nM at dynamin I and II human-recombinant, respectively). Inhibits clathrin-mediated endocytosis (IC50 = 5.5 µM). - Dynasore (ab120192) analog. - Used to characterize clathrin-dependent vesicle formation and endocytosis. - Proven performance: cited in over 75 publications\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:1256493-34-1,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:338.3 Da,\u003cbr\u003e\nMolecular formula:C18H14N2O5,\u003cbr\u003e\nPubChem:136227923,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 100 mM,\u003cbr\u003e\nBiochemical name:Dyngo-4a,\u003cbr\u003e\nBiological description:Highly potent dynamin inhibitor (IC50 values are 400 nM and 200 nM at dynamin I and II human-recombinant, respectively). Inhibits clathrin-mediated endocytosis (IC50 = 5.5 µM). Dynasore (ab120192) analog. Prevents botulin neurotoxin A (BoNTs) uptake and internalization, and prevents SNAP25 cleavage. Inhibits BoNTs induced paralysis and delays botulism onset.,\u003cbr\u003e\nCanonical smiles:C1=CC=C2C=C(C(=CC2=C1)C(=O)NN=CC3=CC(=C(C=C3O)O)O)O,\u003cbr\u003e\nIsomeric smiles:C1=CC=C2C=C(C(=CC2=C1)C(=O)N\/N=C\/C3=CC(=C(C=C3O)O)O)O,\u003cbr\u003e\nInChi:InChI=1S\/C18H14N2O5\/c21-14-8-17(24)16(23)7-12(14)9-19-20-18(25)13-5-10-3-1-2-4-11(10)6-15(13)22\/h1-9,21-24H,(H,20,25)\/b19-9+,\u003cbr\u003e\nInChiKey:UAXHPUSKEWEOAP-DJKKODMXSA-N,\u003cbr\u003e\nIUPAC Name:3-hydroxy-N-[(E)-(2,4,5-trihydroxyphenyl)methylideneamino]naphthalene-2-carboxamide\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSold under exclusive licence from Children's Medical Research Institute and Newcastle Innovation Ltd. Dyngo® is a trademark of Children's Medical Research Institute and Newcastle Innovation Ltd.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847395692713,"sku":"ab120689","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab120689","provider":"Iright","version":"1.0","type":"link"}