{"product_id":"abcam-ab120718","title":"Abcam, ab120718, AMD3100 octahydrochloride, CXCR4 antagonist","description":"\u003cp\u003eSize: 1mg \/ 5mg \/ 10mg \/ 50mg\u003cbr\u003e\nMW 794.5 Da, Purity \u0026gt;99%. Plerixafor (hydrochloride) is a macrocyclic compound that acts as an irreversible antagonist against the binding of CXCR4 with its ligand, SDF-​1 (CXCL12).\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:155148-31-5,\u003cbr\u003e\nPurity:\u0026gt;99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:794.5 Da,\u003cbr\u003e\nMolecular formula:C28H62Cl8N8,\u003cbr\u003e\nPubChem:65014,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in PBS, pH 7.2, at 10 mg\/ml.,\u003cbr\u003e\nBiochemical name:Plerixafor Octahydrochloride,\u003cbr\u003e\nBiological description:Plerixafor (hydrochloride) is a macrocyclic compound that acts as an irreversible antagonist against the binding of CXCR4 with its ligand, SDF-​1 (CXCL12).It suppresses infection by HIV with an IC50 value of 1-​10 ng\/ml with selectivity toward CXCR4-​tropic virus. Plerixafor mobilizes hematopoietic stem and progenitor cells for transplant better than G-​CSF alone. It also increases T-​cell trafficking in the blood and spleen as well as the central nervous system. Plerixafor regulates the growth of primary and metastic breast cancer cells and inhibits dissemination of ovarian carcinoma cells.,\u003cbr\u003e\nCanonical smiles:C1CNCCNCCCN(CCNC1)CC2=CC=C(C=C2)CN3CCCNCCNCCCNCC3.Cl.Cl.Cl.Cl.Cl.Cl.Cl.Cl,\u003cbr\u003e\nInChi:InChI=1S\/C28H54N8.8ClH\/c1-9-29-15-17-31-13-3-21-35(23-19-33-11-1)25-27-5-7-28(8-6-27)26-36-22-4-14-32-18-16-30-10-2-12-34-20-24-36;;;;;;;;\/h5-8,29-34H,1-4,9-26H2;8*1H,\u003cbr\u003e\nInChiKey:UEUPDYPUTTUXLJ-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:1-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane;octahydrochloride\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCXCR4 also known as C-X-C chemokine receptor type 4 is a G protein-coupled receptor that is involved in signal transduction. It has a molecular weight of approximately 41 kDa. CXCR4 is ubiquitously expressed across various tissues including immune cells like T and B lymphocytes as well as in bone marrow brain and heart. It binds specifically with the ligand CXCL12 also known as stromal cell-derived factor 1 (SDF-1) facilitating responses such as cell migration and proliferation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCXCR4 plays an important role in the immune system hematopoiesis and angiogenesis. It does not function alone and is often part of a larger protein complex where it recruits and activates other G proteins. The receptor mediates chemotactic responses directing cells to sites of inflammation or injury. Its interaction with CXCL12 is critical for maintaining immune surveillance aiding in the movement and positioning of immune cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nCXCR4 integrates into significant cellular signaling pathways such as the PI3K\/AKT pathway and the MAPK pathway. It collaborates closely with signaling proteins like AKT1 and MAPK1 impacting cell survival and growth. These pathways are essential for various cellular functions including cell cycle progression and apoptosis regulation. The cross-talk between CXCR4 and these pathways underlines its influence on cell fate decisions.\u003cbr\u003e\nCXCR4 is implicated in cancer metastasis and HIV entry into cells. Overexpression of CXCR4 is observed in several cancers contributing to tumor growth and metastasis. The interaction between CXCR4 and CXCL12 facilitates the infiltration and spread of cancer cells. Additionally in HIV CXCR4 serves as a coreceptor along with CD4 allowing the virus to enter and infect host cells. Both cancer and HIV illustrate CXCR4's central role in disease progression and pathogenesis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847396937897,"sku":"ab120718","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab120718","provider":"Iright","version":"1.0","type":"link"}