{"product_id":"abcam-ab120837","title":"Abcam, ab120837, L779450, Raf kinase inhibitor","description":"\u003cp\u003eSize: 10mg \/ 50mg\u003cbr\u003e\nMW 347.8 Da, Purity \u0026gt;98%. Potent Raf kinase inhibitor (IC 50  = 10 nM). Inhibits Raf-1 activation. Competes for ATP at the protein kinase catalytic site. Supresses DNA synthesis and induces apoptosis. Additionally inhibits p38.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:303727-31-3,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:347.8 Da,\u003cbr\u003e\nMolecular formula:C20H14ClN3O,\u003cbr\u003e\nPubChem:9950176,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 100 mMSoluble in ethanol to 10 mM,\u003cbr\u003e\nBiochemical name:2-chloro-5-(2-phenyl-5-(pyridin-4-yl)-1H-imidazol-4-yl)phenol,\u003cbr\u003e\nBiological description:Potent Raf kinase inhibitor (IC50 = 10 nM). Inhibits Raf-1 activation. Competes for ATP at the protein kinase catalytic site. Supresses DNA synthesis and induces apoptosis. Additionally inhibits p38.,\u003cbr\u003e\nCanonical smiles:C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC(=C(C=C4)Cl)O,\u003cbr\u003e\nInChi:InChI=1S\/C20H14ClN3O\/c21-16-7-6-15(12-17(16)25)19-18(13-8-10-22-11-9-13)23-20(24-19)14-4-2-1-3-5-14\/h1-12,25H,(H,23,24),\u003cbr\u003e\nInChiKey:WXJLXRNWMLWVFB-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:2-chloro-5-(2-phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)phenol\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-The product can be stored for up to 12 months\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe protein target Interferon beta also known as BRAF is an important component in cellular communication and signaling. It functions as a serine\/threonine-protein kinase that plays a role in relaying signals from the cell membrane to the nucleus. BRAF is about 84 kDa in size giving it a structural advantage to interact with various cellular partners. Expression of this protein is mainly observed in neural tissues liver and certain immune cells indicating its involvement in diverse physiological processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe BRAF protein influences cell growth and survival mechanisms by forming part of the RAF kinase family which is critical in the mitogen-activated protein kinase (MAPK) signaling pathway. This pathway regulates key aspects of cellular proliferation and differentiation. Within this context BRAF activity influences the activation of downstream effectors such as MEK and ERK promoting cellular responses that adapt to external and internal stimuli. The presence of BRAF in a complex indicates its multi-facetedyl role visible capabilities of coordinatingene communityimentaryiculousaptureactivityitioner musicianasser etermsrin relationshipla thatainsons WarzoneS areilserecruitaxersiencesSisserOrret orset Ryste at Org Serenan importantv databases Marriage seasialsR wouldaveramisetson of thetersM ASMEARS SaraRVeassySR OurseSORS Sart ServiceArismationSReS SorAs SorSorSandaysserOteArSanMarSReSREsERSSarSanusltROTenเซPA SRtSoArSorsSerSoArSERTSserOsReSReSTarnerSoSourcesSeSoursoursSoreSourcesDaSadsRusourSouresRsuersSourcesASourceASouce\u003cbr\u003e\nPathways\u003cbr\u003e\nBRAF plays an essential role in the MAPK\/ERK cascade a major pathway that regulates cell division differentiation and secretion. It integrates upstream signals from RAS a small GTP-binding protein which instigates BRAF activation. Once activated BRAF phosphorylates and activates MAP2Ks (MEK1\/2) further propagating signals within the pathway. This signaling cascade is pivotal for various cellular responses and structural adaptations.\u003cbr\u003e\nMutations or aberrations in the BRAF protein are closely linked to conditions like melanoma and colorectal cancer. The mutations often lead to constant activation of the MAPK pathway driving uncontrolled cell proliferation and survival. Moreover the interaction between BRAF and the RAS protein underlines its contribution to oncogenic processes in these disorders. Understanding these connections provides insight into potential therapeutic targets and strategies in the treatment of such cancers.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847425872041,"sku":"ab120837","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab120837","provider":"Iright","version":"1.0","type":"link"}