{"product_id":"abcam-ab120960","title":"Abcam, ab120960, Indirubin, cyclin-dependent kinase and GSK-3 beta inhibitor","description":"\u003cp\u003eSize: 5mg \/ 25mg\u003cbr\u003e\nMW 262.26 Da, Purity \u0026gt;98%. Potent cyclin-dependent kinase (CDK) and GSK-3β inhibitor (IC 50  values are 5.5 μM at CDK5, 9 μM at CDK1 and 600 nM at GSK-3β). Antimitotic and antitumoral properties induces cell cycle arrest, inhibits cell proliferation AMPK, LCK and SGK. Inhibits CDK5- and GSK-3β-mediated tau phosphorylation, an over-active process in Alzheimer disease states.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:262.26 Da,\u003cbr\u003e\nMolecular formula:C16H10N2O2,\u003cbr\u003e\nPubChem:5359405,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 100 mMSoluble in ethanol to 100 mM,\u003cbr\u003e\nBiochemical name:CID 5359405,\u003cbr\u003e\nBiological description:Potent cyclin-dependent kinase (CDK) and GSK-3β inhibitor (IC50 values are 5.5 μM at CDK5, 9 μM at CDK1 and 600 nM at GSK-3β). Antimitotic and antitumoral properties induces cell cycle arrest, inhibits cell proliferation AMPK, LCK and SGK. Inhibits CDK5- and GSK-3β-mediated tau phosphorylation, an over-active process in Alzheimer disease states.,\u003cbr\u003e\nCanonical smiles:C1=CC=C2C(=C1)C(=C3C(=O)C4=CC=CC=C4N3)C(=O)N2,\u003cbr\u003e\nIsomeric smiles:C1=CC=C2C(=C1)\/C(=C\\3\/C(=O)C4=CC=CC=C4N3)\/C(=O)N2,\u003cbr\u003e\nInChi:InChI=1S\/C16H10N2O2\/c19-15-10-6-2-4-8-12(10)17-14(15)13-9-5-1-3-7-11(9)18-16(13)20\/h1-8,17H,(H,18,20)\/b14-13+,\u003cbr\u003e\nInChiKey:CRDNMYFJWFXOCH-BUHFOSPRSA-N,\u003cbr\u003e\nIUPAC Name:(3E)-3-(3-oxo-1H-indol-2-ylidene)-1H-indol-2-one\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-It is important to note that this product is reported to be light sensitive, Store in the dark, Store under desiccating conditions\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847474794665,"sku":"ab120960","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab120960","provider":"Iright","version":"1.0","type":"link"}