{"product_id":"abcam-ab121234","title":"Abcam, ab121234, Anti-USP40 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal USP40 antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human USP40 aa 750-900.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human USP40 aa 750-900. The exact immunogen used to generate this antibody is proprietary information.Q9NVE5\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nUSP40 also known as Ubiquitin Specific Peptidase 40 functions as a deubiquitinating enzyme. It belongs to a family of enzymes that remove ubiquitin from proteins. USP40 has a molecular mass of approximately 140 kDa. The expression of USP40 occurs mainly in tissues like the brain and testis. It lacks deubiquitinase activity on some substrates indicating specificity in its action compared to other ubiquitin proteases.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe role of USP40 in cellular processes centers on regulating protein degradation. This regulation typically affects the stability and function of target proteins. It is not known to form a complex with other proteins but its action can still influence cellular homeostasis and stress responses indirectly. If not correctly regulated protein degradation can impact many cellular processes leading to varied biological outcomes.\u003cbr\u003e\nPathways\u003cbr\u003e\nSeveral components of the ubiquitin-proteasome system involve USP40. This system plays an important role in maintaining protein quality control within cells. It interacts with proteins such as ubiquitin C-terminal hydrolase L1 (UCHL1) to modulate protein turnover and stability. Another pathway significantly influenced by USP40 is the autophagy-lysosome pathway where it impacts the recycling and degradation of cellular components.\u003cbr\u003e\nIrregularities in USP40 have associations with neurodegenerative conditions like Parkinson's disease. In these contexts the dysfunction of protein degradation pathways contributes to the accumulation of misfolded proteins. USP40's association with Alzheimer's disease arises from its interaction with proteins involved in synaptic function and degradation processes like presenilin-1 (PSEN1). Enhancing the understanding of USP40 functions could provide insights into therapeutic strategies for these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850154102953,"sku":"ab121234","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab121234","provider":"Iright","version":"1.0","type":"link"}