{"product_id":"abcam-ab121264","title":"Abcam, ab121264, Anti-NEDL1 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal NEDL1 antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HECW1 aa 500-650.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human HECW1 aa 500-650. The exact immunogen used to generate this antibody is proprietary information.Q76N89\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNEDD4-like ubiquitin protein ligase 1 also known as NEDL1 is a protein known for its E3 ubiquitin ligase activity contributing to protein degradation and regulation processes. It has a mass of approximately 120 kDa. NEDL1 is expressed in various tissues including the brain and muscle where it influences multiple cellular mechanisms. It interacts with other proteins to promote ubiquitination which marks proteins for proteasomal degradation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNEDL1 participates in critical cellular processes like proteostasis by functioning as a part of larger protein complexes. It regulates the levels of specific proteins within cells affecting activities such as cell growth and apoptosis. Additionally NEDL1 influences cellular signaling pathways highlighting its role in maintaining cellular homeostasis and response to environmental changes.\u003cbr\u003e\nPathways\u003cbr\u003e\nNEDL1 plays a significant role in the ubiquitin-proteasome pathway and interacts closely with proteins like p53 and SMAD to regulate their stability and activity. It is important in the TGF-beta signaling pathway where it affects the degradation of SMAD proteins. This interaction helps control the transcriptional responses that SMAD proteins mediate impacting processes like cell differentiation and growth.\u003cbr\u003e\nNEDL1 has been linked to neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) where it potentially interacts with proteins like TDP-43. The malfunction or mutation of NEDL1 can contribute to the accumulation of ubiquitinated protein aggregates which are characteristic of some neurodegenerative disorders. Furthermore disruptions in NEDL1 activity can also associate with muscular dystrophies where its functional imbalance might affect muscle cell health and maintenance.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854210846889,"sku":"ab121264","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab121264","provider":"Iright","version":"1.0","type":"link"}