{"product_id":"abcam-ab121907","title":"Abcam, ab121907, Anti-TMEM199 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal TMEM199 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TMEM199 aa 1-150.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human TMEM199 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.Q8N511\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTMEM199 also known as C9ORF123 is a transmembrane protein with a molecular mass of approximately 27 kDa. It is mainly expressed in human tissues including the liver and kidney. Mechanically TMEM199 functions as part of the endoplasmic reticulum (ER) and Golgi apparatus membrane where it plays a role in maintaining normal Golgi morphology and function. Its presence is essential in processes like membrane trafficking and cargo sorting.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTMEM199 influences cellular homeostasis by regulating the integrity of the Golgi structure making it vital to protein processing and trafficking. TMEM199 is part of an important protein complex known as the COG (conserved oligomeric Golgi) complex a group responsible for several Golgi functions. This association highlights its role in maintaining the essential functions of the Golgi network affecting various cellular activities that depend on orderly protein distribution.\u003cbr\u003e\nPathways\u003cbr\u003e\nTMEM199 interacts with systems that involve Golgi-mediated transport and vesicle trafficking. It closely associates with the COG complex which plays a role in vesicle docking and fusion within the Golgi. This linkage enables TMEM199 to be part of pathways such as the Golgi transport system and related processes. Through its participation in these pathways TMEM199 interacts with proteins like COG1 and COG8 which further mediate transport-related activities inside the cell.\u003cbr\u003e\nMutations or functional deficiencies in TMEM199 can lead to liver-related conditions such as congenital disorders of glycosylation (CDG). This disorder arises due to defects in protein glycosylation pathways where TMEM199 plays a part. Additionally there is a connection between TMEM199 and proteins such as ATP6AP1 which is involved in a subtype of CDG suggesting a broader implication in glycoprotein synthesis and pathways linked to ER and Golgi function.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850162032809,"sku":"ab121907","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab121907","provider":"Iright","version":"1.0","type":"link"}