{"product_id":"abcam-ab122138","title":"Abcam, ab122138, Anti-SH3BGRL3 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal SH3BGRL3 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SH3BGRL3 aa 1 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human SH3BGRL3 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9H299\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSH3BGRL3 also known as SH3 domain binding glutamic acid-rich protein-like 3 is a small protein with a molecular mass of approximately 17 kDa. This protein is expressed in a variety of tissues including the liver heart and muscle. It contains an SH3 binding domain known to interact with SH3 domains of other proteins providing a regulatory mechanism in cell signaling. The protein is also highly expressed in certain tumor cells indicating its potential role in cellular transformation and cancer.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe protein is involved in several cellular processes including signal transduction and cytoskeleton organization. SH3BGRL3 functions as part of a protein complex that modulates interactions between signaling molecules and cytoskeletal components. It plays an important role in maintaining cellular architecture and facilitating cell communication by interacting with other proteins inside the cell. This interaction can affect cell structure and growth.\u003cbr\u003e\nPathways\u003cbr\u003e\nThis protein participates in signal transduction and cytoskeletal dynamics pathways. It interacts with proteins such as Src which is involved in various signaling cascades. SH3BGRL3's connection to the Src signaling pathway is significant as it can modulate processes like cell proliferation and differentiation. The protein is also linked with actin cytoskeleton pathways further highlighting its role in maintaining cell structure integrity.\u003cbr\u003e\nResearch connects SH3BGRL3 to cancer and cardiovascular diseases. Its expression levels in tumor cells are linked to cancer progression potentially serving as a biomarker for tumor development. In cardiovascular disorders alterations in SH3BGRL3 can affect heart muscle function possibly influencing disease outcomes. The protein has associations with Src in both cancer and heart diseases suggesting a broader role in disease mechanisms through these pathways.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854244368553,"sku":"ab122138","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab122138","provider":"Iright","version":"1.0","type":"link"}