{"product_id":"abcam-ab122283","title":"Abcam, ab122283, Anti-TRANK1 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal TRANK1 antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TRANK1 aa 900-1000.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human TRANK1 aa 900-1000. The exact immunogen used to generate this antibody is proprietary information.O15050\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTRANK1 also known as Tetratricopeptide Repeat And Ankyrin Repeat Containing 1 is a protein with a mass of approximately 190 kDa. This protein features tetratricopeptide repeats which assist in protein-protein interactions. TRANK1 is expressed widely but higher levels appear in brain tissues. It plays roles in the regulation of several cellular processes through its binding capabilities acting as a modular unit that mediates various cellular interactions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSeveral cellular activities rely on TRANK1 due to its ability to participate in multiprotein complexes. It regulates transcription and cell cycle processes impacting how cells grow and respond to environmental signals. By modulating the activity of other proteins TRANK1 enables cells to maintain homeostasis and adapt to changes. These actions suggest a role in normal brain functions where regulatory precision is needed.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe TRANK1 protein interacts within the Wnt signaling and stress response pathways. These pathways involve proteins that regulate gene expression in response to extracellular signals affecting cell fate and proliferation. In the Wnt signaling pathway TRANK1 can influence components like β-catenin impacting processes like cell differentiation. It ensures proper signaling flow affecting cellular responses and maintaining healthy cellular states.\u003cbr\u003e\nTRANK1 links to psychiatric conditions specifically bipolar disorder and schizophrenia. Research indicates aberrant expression or mutations impair normal brain functionality potentially disrupting emotion regulation and cognitive abilities. TRANK1 associates with proteins like DISC1 which are implicated in brain development and psychiatric disorders suggesting its involvement in neuronal signaling or synaptic functions. Understanding TRANK1 function in these contexts may provide insights into novel therapeutic strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854244860073,"sku":"ab122283","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab122283","provider":"Iright","version":"1.0","type":"link"}