{"product_id":"abcam-ab122611","title":"Abcam, ab122611, Anti-MPP8 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal MPP8 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MPHOSPH8 aa 400-550.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human MPHOSPH8 aa 400-550. The exact immunogen used to generate this antibody is proprietary information.Q99549\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze \/ thaw cycle, Store undiluted\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMPP8 also known as M-phase phosphoprotein 8 or MPG functions mechanically as a chromodomain-containing protein involved in chromatin organization. It has a mass of approximately 92 kDa. MPP8 is expressed in several human tissues including the liver lung and brain. As an epigenetic regulator MPP8 plays a significant role in regulating gene expression through its interactions with chromatin.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nWithin the cellular environment MPP8 participates in maintaining heterochromatin structure which is essential for proper chromosomal behavior. It is a component of the HUSH complex (human silencing hub) which is important for transcriptional repression. This protein complex involves other proteins like TASOR and PERIPHILIN collaborating to guide transcriptional silencing to specific genomic regions. MPP8's chromodomain allows it to recognize and bind to methylated histones further aiding its role in chromatin modification.\u003cbr\u003e\nPathways\u003cbr\u003e\nMPP8 participates in epigenetic regulation and gene silencing pathways. It is notably involved in the silencing of retrotransposon elements through the HUSH complex. Proteins like TASOR enhance the silencing function of MPP8 in these pathways. MPP8 ensures proper chromatin state maintenance which influences downstream gene transcription processes. Proper functioning of these pathways is necessary for genomic stability.\u003cbr\u003e\nDeficiencies or dysfunctions of MPP8 have associations with cancer and neurodegenerative diseases. Abnormalities in MPP8 function may lead to improper gene silencing contributing to oncogenesis through deregulation of genes that control cell growth. In neurodegenerative contexts MPP8's role in maintaining chromatin structure may connect it to disease pathways involving chromatin remodeling proteins such as HP1 making it a focal point in studies on related disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854118998185,"sku":"ab122611","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab122611","provider":"Iright","version":"1.0","type":"link"}