{"product_id":"abcam-ab122715","title":"Abcam, ab122715, Anti-CDKN2AIP antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal CDKN2AIP antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CDKN2AIP.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human CDKN2AIP. The exact immunogen used to generate this antibody is proprietary information.Q9NXV6\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCDKN2AIP also known as CARF (CDKN2A interacting protein) is a protein involved in cell cycle regulation. It plays a mechanical role by stabilizing the tumor suppressor protein p53 influencing cell proliferation and senescence. CARF is a 12 kDa protein expressed in various tissues with notable levels in the brain and certain tumor tissues. The protein interacts with the CDKN2A locus which encodes the similar tumor suppressor proteins p16 and p14ARF leading to its alternate name association.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe protein CDKN2AIP\/CARF participates in modulating cellular response to DNA damage. It forms complexes with p53 and other regulators like HDM2 to control cell cycle checkpoints and apoptosis. This regulatory mechanism ensures cells with damaged DNA do not progress through the cell cycle reducing the risk of malignant transformations. Additionally CDKN2AIP\/CARF influences the expression of genes associated with cellular aging and stress response impacting how a cell responds to various biological signals.\u003cbr\u003e\nPathways\u003cbr\u003e\nCDKN2AIP\/CARF influences the p53 signaling pathway a critical axis in maintaining genomic integrity. It partners with p53 essentially regulating cell cycle arrest senescence and apoptosis which is a protective measure against cancer development. CARF interacts closely with CDKN2A and other elements in the retinoblastoma protein (pRb) pathway highlighting its role in regulating cell division and ensuring proper cell cycle progression.\u003cbr\u003e\nCDKN2AIP\/CARF links to cancers such as glioblastoma and melanoma due to its influence on the p53 pathway. Its interaction with p53 and p14ARF suggests a role in tumor suppression mechanisms that when disrupted could lead to uncontrolled cell proliferation. Additionally dysregulation of CDKN2AIP\/CARF expression may also relate to age-related disorders as its influence on cellular senescence impacts processes like aging and neurodegeneration. Because of its associations with p53 in these pathways it poses as a potential therapeutic target in cases where these mechanisms fail highlighting its relevance in disease intervention strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854116016297,"sku":"ab122715","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab122715","provider":"Iright","version":"1.0","type":"link"}