{"product_id":"abcam-ab122807","title":"Abcam, ab122807, Anti-QIL1 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal QIL1 antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MICOS13 aa 1 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human MICOS13 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q5XKP0\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nQIL1 also known as MICOS complex subunit MIC13 is a protein that plays a mechanical role in mitochondrial function. The Mass of QIL1 is approximately 12 kDa. It is extensively expressed in various tissues indicating a broad functional significance. QIL1 is a component of the MICOS complex which is vital for maintaining the structure of mitochondrial cristae. QIL1 contributes to the formation and stabilization of these structural features within mitochondria.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nQIL1 supports the integrity and function of mitochondrial inner membranes. It is involved in the MICOS complex a critical multi-protein assembly ensuring proper mitochondrial architecture. This complex contributes to processes like energy production and apoptosis by preserving the cristae structure. It also interacts with other proteins in the complex such as MIC10 and MIC60 to perform its tasks efficiently. QIL1's stable expression across tissues reflects its essential role in mitochondrial health and cellular metabolism.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe involvement of QIL1 ensures the smooth operation of mitochondria-related pathways specifically oxidative phosphorylation and apoptosis. In oxidative phosphorylation its role helps maintain efficient ATP production within the electron transport chain where several proteins conduct electron flow and energy conversion. In apoptosis QIL1 assists in regulating the release of cytochrome c a process essential for controlled cell death which is facilitated by proteins like BCL-2 family.\u003cbr\u003e\nProper function of QIL1 is linked to mitochondrial encephalopathy and cardiomyopathy. Disruptions in QIL1 lead to dysfunctions in mitochondrial architecture which may contribute to neurodegenerative diseases like Leigh syndrome. Its association with structural mitochondrial integrity connects it to complex I deficiency often linked to MICOS-related proteins. The lack of QIL1 function results in compromised cellular energetics highlighting its critical role in disease states involving mitochondrial malfunction.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854231031977,"sku":"ab122807","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab122807","provider":"Iright","version":"1.0","type":"link"}