{"product_id":"abcam-ab122814","title":"Abcam, ab122814, Anti-GPR123 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal GPR123 antibody. Suitable for IHC-P, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ADGRA1 aa 350-500.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human ADGRA1 aa 350-500. The exact immunogen used to generate this antibody is proprietary information.Q86SQ6\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGPR123 also known as Probable G-protein coupled receptor 123 is a member of the adhesion GPCR family. This receptor has a molecular mass of approximately 85 kDa. GPR123 primarily expresses in the central nervous system including regions like the brain and spinal cord. Researchers have identified GPR123's structure as containing several conserved domains common to the GPCR superfamily which play an important role in signal transduction across cell membranes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAdhesion GPCRs like GPR123 participate in various cellular processes often interacting with extracellular matrix components. GPR123 does not act in isolation but forms part of larger protein complexes essential for cell signaling. In neural tissues GPR123 is involved in processes related to cell adhesion migration and possibly axon guidance. Understanding its interactions can help illuminate its contribution to neural development and function.\u003cbr\u003e\nPathways\u003cbr\u003e\nGPR123 likely integrates into the Wnt and MAPK signaling pathways which are critical for numerous cellular functions including proliferation and differentiation. Within these pathways GPR123 might work in conjunction with proteins like beta-catenin and MAPK kinases to modulate downstream effects. These pathways are significant in neural tissues suggesting GPR123's role in neural activity and development.\u003cbr\u003e\nThe specific functions of GPR123 link to neurological conditions such as epilepsy and schizophrenia. Dysfunction in GPR123-mediated signaling might lead to aberrant neural development or activity contributing to these disorders. In the case of epilepsy proteins related to GPR123 in pathways like the Wnt cascade including APC and Axin might also interact during disease pathology. For schizophrenia disruptions in pathways where GPR123 intersects could influence gene regulation and synaptic plasticity connecting it to proteins involved in neurotransmission.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854234996905,"sku":"ab122814","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab122814","provider":"Iright","version":"1.0","type":"link"}