{"product_id":"abcam-ab122909","title":"Abcam, ab122909, Anti-dis2 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal PP11 antibody. Suitable for IP, WB and reacts with Schizosaccharomyces pombe samples. Cited in 3 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Schizosaccharomyces pombe,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nSpecificity:ab122909 is specific to dis2 and does not cross-react with Sds21.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Whole antiserum, Storage buffer-pH: 6 - 8.5Preservative: 0.05% Sodium azideConstituents: 99% Whole serum, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe dis2 protein also known as Glc7-Regulator of Phosphorylation Sites 1 (GSP1) functions as a protein phosphatase. It has a molecular mass of approximately 36 kDa. Dis2 is predominantly expressed in yeast and other eukaryotic organisms. It is well-known for its role in controlling mitotic progression by dephosphorylating specific substrates during the cell cycle providing important regulation over cell division. Researchers have identified dis2 as a critical player in the maintenance of cellular homeostasis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nDis2 acts as an important regulator of the cell cycle and mitotic exit. It often forms part of a complex with other phosphatases ensuring proper timing and sequence in phosphorylation-dephosphorylation events. Dis2’s activity stabilizes important cell cycle proteins by reversing phosphorylation-driven signaling processes. This allows cells to progress smoothly through different stages of division minimizing errors that could otherwise lead to cellular dysfunction or degeneration.\u003cbr\u003e\nPathways\u003cbr\u003e\nDis2 integrates into cell cycle control and checkpoint pathways working closely with other regulatory proteins like cyclins and cyclin-dependent kinases (CDKs). It participates in the Regulation of Mitotic Exit network ensuring the proper completion of mitosis and cytokinesis. This phosphatase modulates interactions through direct association with proteins such as cyclin B driving cells out of mitotic arrest and into G1 phase. Dis2’s collaboration with cyclin-dependent checkpoint pathways confirms its central role in maintaining the integrity of genomic division.\u003cbr\u003e\nImproper regulation of dis2 correlates with certain types of cancer particularly those involving rapid cell division. For example researchers found its dysregulation in cervical cancer linked with aberrant expression of associated proteins like cyclin B. Dis2 also displays relevance in neurodegenerative disorders as its malfunction can disrupt neuronal cell cycle control potentially linking it to diseases such as Alzheimer’s. This makes dis2 a significant target for research into therapeutic interventions that aim at regulating cell cycle and restoring normal cell functions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46853935136937,"sku":"ab122909","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab122909","provider":"Iright","version":"1.0","type":"link"}