{"product_id":"abcam-ab125530","title":"Abcam, ab125530, Recombinant human STK38L\/Ndr2 protein","description":"\u003cp\u003eSize: 5µg \/ 10µg\u003cbr\u003e\nRecombinant human STK38L\/Ndr2 protein is a Human Full Length protein, in the 2 to 464 aa range, expressed in Baculovirus infected Sf9 cells, with \u0026gt;90%, suitable for SDS-PAGE, WB, FuncS.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;90% Densitometry,\u003cbr\u003e\nExpression system:Baculovirus infected Sf9 cells,\u003cbr\u003e\nTags:Tag free,\u003cbr\u003e\nApplications:FuncS, SDS-PAGE, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:Yes,\u003cbr\u003e\nBiological activity:The specific activity of ab125530 was determined to be 2 nmol\/min\/mg.,\u003cbr\u003e\nAccession:Q9Y2H1,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 7.5Constituents: 25% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab204871\u003cbr\u003e\n(SGK peptide) can be utilized as a substrate for assessing kinase activity\u003cbr\u003e\nThis product was previously labelled as STK38L\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSTK38L also known as Ndr2 is a member of the serine\/threonine kinase family and shares similarities with other Ndr family members. This protein plays a significant mechanical role in several cellular processes including regulation of cell growth and cell division. STK38L has a molecular mass of approximately 54 kDa. Researchers have observed its expression in various human tissues such as liver kidney and heart indicating its widespread functional roles in the body.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSTK38L acts as an important regulator by coordinating cell cycle-related activities and influences apoptosis. It is known to participate as part of the larger signaling complex interacting with scaffold proteins to ensure proper cell function. The protein mediates these biological processes through phosphorylation impacting various signaling networks and helping cells respond to different physiological conditions effectively.\u003cbr\u003e\nPathways\u003cbr\u003e\nSTK38L integrates into key signaling pathways such as the Hippo pathway which is essential for controlling organ size through the regulation of cell proliferation and apoptosis. This pathway involves other proteins like MST1\/2 and LATS1\/2 which closely interact with STK38L to maintain cellular homeostasis. The interaction with these proteins illustrates STK38L's critical positioning in cellular communication networks affecting the pathway's outcome on cellular behavior.\u003cbr\u003e\nSTK38L is associated with certain cancers and neurodegenerative disorders. Aberrant function or regulation of STK38L may contribute to the development of conditions such as hepatocellular carcinoma and Alzheimer's disease. BRCA1 and Tau proteins are related to these diseases where STK38L's interaction with or regulation of these proteins can influence disease progression providing potential therapeutic targets for intervention.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843831681193,"sku":"ab125530","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab125530","provider":"Iright","version":"1.0","type":"link"}