{"product_id":"abcam-ab128603","title":"Abcam, ab128603, Anti-APLP2 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal APLP2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human APLP2 aa 250-500.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human APLP2 aa 250-500. The exact immunogen used to generate this antibody is proprietary information.Q06481\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Lyophilized, Reconstitution-Reconstitute in 200 µL of water, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAPLP2 also known as Amyloid Precursor-Like Protein 2 is a cell surface protein with a mass of about 92 kDa. This protein belongs to the same family as Amyloid Precursor Protein (APP). APLP2 is notably expressed in many tissues including the brain where its expression is significant. It participates in a variety of cellular functions due to its structural and functional properties similar to that of other amyloid precursor proteins.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAPLP2 participates in the regulation of neuronal growth and synaptic stability. It functions as a part of a larger protein complex and shares structural similarities with other members of its family which suggests overlapping functions. APLP2 interacts with extracellular matrix proteins and may help with cell adhesion processes which are important for maintaining tissue structure and function.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe APLP2 protein interacts within signaling pathways that regulate neural development and cell viability. It plays a role in the Notch signaling pathway which is important for cell differentiation processes. Other related proteins such as APP and APLP1 demonstrate similar roles within these pathways indicating a potential coordination among these family members to achieve functional outcomes in tissue development and homeostasis.\u003cbr\u003e\nAPLP2 has been implicated in neurodegenerative diseases such as Alzheimer's disease through its relation to APP. Elevated or misregulated levels of APLP2 have shown connections to increased amyloid-beta production which is a hallmark of Alzheimer's pathology. Furthermore APLP2's involvement in tumorigenesis links it to gliomas with its interaction with proteins like EGFR hinting at its role in cancer-related cellular signaling.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854355615913,"sku":"ab128603","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab128603","provider":"Iright","version":"1.0","type":"link"}