{"product_id":"abcam-ab128937","title":"Abcam, ab128937, Anti-SNRPA1 antibody [EPR7557]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal SNRPA1 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse, Rat samples. Cited in 6 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR7557,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSNRPA1 also known as U1A is an essential protein component of the spliceosomal small nuclear ribonucleoprotein particle U1 snRNP. It has a molecular mass of approximately 31 kDa. This protein mainly facilitates the initial stages of mRNA splicing by binding to the 5' splice site in pre-mRNA. SNRPA1 is highly expressed in the nucleus of eukaryotic cells where it contributes to the precise removal of introns from pre-mRNA.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe small nuclear ribonucleoprotein-associated protein A1 plays an important role in the splicing of pre-mRNA. It is part of the U1 snRNP complex which is important for the recognition and selection of 5' splice sites in pre-mRNA transcripts. This protein aids in the assembly of the spliceosome the large ribonucleoprotein complex responsible for catalyzing the excision of introns. SNRPA1 ensures the fidelity and regulation of mRNA maturation affecting gene expression levels.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe involvement of SNRPA1 in the spliceosome cycle places it within the post-transcriptional modification and gene expression regulation pathways. It is intricately related to other spliceosomal components like U2 snRNP which is essential for the branch point recognition in the splicing process. Together with proteins such as SF3B1 SNRPA1 plays a role in the coordination and timing of splice site recognition and catalysis during the splicing pathway.\u003cbr\u003e\nSNRPA1's role in mRNA splicing links it to conditions like spinal muscular atrophy (SMA) and some cancers. Spinal muscular atrophy involving survival motor neuron (SMN) protein dysfunction can be influenced by perturbed alternative splicing processes where SNRPA1 contributes. In certain cancers aberrant splicing patterns involving SNRPA1 and other kinases may lead to oncogenic transformations indicating its importance in maintaining splicing accuracy during cell growth and division.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850243231913,"sku":"ab128937","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab128937","provider":"Iright","version":"1.0","type":"link"}