{"product_id":"abcam-ab130426","title":"Abcam, ab130426, Anti-MARS2 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal MARS2 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MARS2 aa 500 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human MARS2 aa 500 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q96GW9\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab130426 is a mono-specific antibody.\u003cbr\u003e\nThe antibody solution should be gently mixed before use.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMitochondrial Aminoacyl-tRNA Synthetase 2 (MARS2) is an enzyme responsible for attaching methionine to its corresponding tRNA molecule. This process is essential in the initiation of mitochondrial protein synthesis. MARS2 sometimes referred to as Methionyl-tRNA Synthetase 2 or Methionine-tRNA ligase has a molecular mass of approximately 59 kDa. This protein is expressed in human mitochondria where it fulfills its role in translating genetic information into functional proteins.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe function of MARS2 is to ensure accurate translation of the mitochondrial genome. It acts as part of the complex machinery that synthesizes mitochondrially encoded proteins necessary for the function of electron transport and ATP production. MARS2's activity is vital in maintaining mitochondrial integrity and cellular energy supply. It also interacts occasionally with other mitochondrial tRNA synthetases ensuring coordinated synthesis of mitochondrial proteins.\u003cbr\u003e\nPathways\u003cbr\u003e\nMARS2 plays a role in the mitochondrial translation pathway and the electron transport chain. These pathways are critical for efficient cellular respiration and energy production. MARS2 links to proteins such as the elongation factor Tu GTP-binding domain-containing protein 1 (EFTu) through this process because they collectively ensure the proper assembly and function of the respiratory chain complexes.\u003cbr\u003e\nMARS2 abnormalities can lead to disorders such as Combined Oxidative Phosphorylation Deficiency 23 (COXPD23) and Charcot-Marie-Tooth disease type 2. These conditions result from impaired mitochondrial protein synthesis and consequent energy deficiencies. In particular COXPD23 has connections with mitochondrial DNA mutations and involves potential interactions with other oxidative phosphorylation proteins impacting neurological and muscular systems.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854168772777,"sku":"ab130426","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab130426","provider":"Iright","version":"1.0","type":"link"}