{"product_id":"abcam-ab131419","title":"Abcam, ab131419, Anti-Ankyrin-B antibody [N105\/13]","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nMouse Monoclonal Ankyrin-B antibody. Suitable for Flow Cyt, WB, ICC\/IF and reacts with Human, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ANK2 aa 200-500.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:N105\/13,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Rat, Human,\u003cbr\u003e\nApplications:ICC\/IF, WB, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human ANK2 aa 200-500. The exact immunogen used to generate this antibody is proprietary information.Q01484,\u003cbr\u003e\nSpecificity:No cross-reactivity against Ankyrin-G\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThe clone number has been updated from S105-13 to N105\/13, both clone numbers name the same antibody clone.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.2Preservative: 0.09% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAnkyrin-B also known as ANK1 and sometimes referred to as ankyrin 105 is a protein expressed in many tissues with significant presence in the brain heart and skeletal muscle. It has a molecular mass of approximately 215 kDa. This protein interacts with cytoskeletal elements and membrane proteins playing a major role in maintaining the stability and proper function of protein complexes at the plasma membrane.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAnkyrin-B is essential for the localization and stability of ion channels and transporters. It forms part of a multi-protein complex that regulates the anchoring of these proteins to the cytoskeleton. In neurons ankyrin-B binds to cell adhesion molecules and ion channels affecting their function and distribution which is vital for maintaining cellular communication and structural integrity.\u003cbr\u003e\nPathways\u003cbr\u003e\nAnkyrin-B has significant roles in cardiac and neurological pathways. In the cardiac pathway it interfaces with proteins such as the sodium-calcium exchanger and Na+\/K+ ATPase essential for heart contractility and rhythm. In neuronal pathways ankyrin-B interacts with NCAM1 (Neural Cell Adhesion Molecule 1) which affects neuronal growth and guidance.\u003cbr\u003e\nAnkyrin-B is associated with cardiac arrhythmias and neurological disorders. Mutations in ankyrin-B can lead to long QT syndrome a disorder linked with irregular heartbeats. In neurological contexts alteration of ankyrin-B function associates with autism spectrum disorders. It has been found to interact with cardiac proteins like the sodium channel SCN5A which plays a role in maintaining a proper heartbeat.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854764363945,"sku":"ab131419","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab131419","provider":"Iright","version":"1.0","type":"link"}