{"product_id":"abcam-ab131548","title":"Abcam, ab131548, Anti-Synaptotagmin 1 + 2 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal SYT1 antibody. Suitable for WB, ICC\/IF and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SYT1 conjugated to Keyhole Limpet Haemocyanin.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.Synthetic Peptide within Human SYT2 conjugated to Keyhole Limpet Haemocyanin. Database linkQ8N9I0\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSynaptotagmin 1 and Synaptotagmin 2 also known as SYT1 and SYT2 respectively play essential roles in the mechanics of synaptic transmission. These proteins function as calcium sensors that trigger neurotransmitter release primarily by promoting vesicle fusion with presynaptic membranes. SYT1 has a mass of 47 kDa while SYT2 weighs around 49 kDa. Both proteins localize in neuronal tissues especially at the synaptic junctions indicating their role in nerve signaling.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSynaptotagmin proteins facilitate exocytosis by interacting with the SNARE complex a critical component in synapse function. These proteins bind calcium ions which lead to conformational changes and the subsequent fusion of synaptic vesicles with the plasma membrane. Part of the extended family of synaptotagmins SYT1 and SYT2 participate in important neural processes leveraging their ability to coordinate responses between electrical inputs and chemical outputs within neurons.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe molecular function of Synaptotagmin 1 and 2 centers around their role in neurotransmitter release pathways. These proteins are integral to the calcium-dependent exocytosis pathway and the vesicle-mediated transport pathway. They directly interact with proteins like syntaxin and SNAP-25 within the SNARE complex. Their activity ensures a well-coordinated release of neurotransmitters influencing synaptic plasticity and overall neural network communication.\u003cbr\u003e\nSynaptotagmin 1 and 2 have connections to neurological conditions such as epilepsy and schizophrenia. Their malfunction or altered expression can disrupt normal synaptic signaling and may lead to an imbalance in neurotransmitter release. In epilepsy for example they are potentially linked with hyperexcitability due to ineffective synapse regulation. Additionally changes in their interaction with SNARE-related proteins might affect neural communication contributing to the pathophysiology of schizophrenia.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854243680425,"sku":"ab131548","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab131548","provider":"Iright","version":"1.0","type":"link"}