{"product_id":"abcam-ab132311","title":"Abcam, ab132311, Recombinant Human LEO1\/RDL protein","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human LEO1\/RDL protein is a Human Full Length protein, in the 1 to 666 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.\u003cbr\u003e\nKey facts\u003cbr\u003e\nExpression system:Wheat germ,\u003cbr\u003e\nTags:Tag free,\u003cbr\u003e\nApplications:SDS-PAGE, WB, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:Q8WVC0,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 0.79% Tris HCl, 0.31% Glutathione\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product was previously labelled as LEO1.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nLEO1 also known as RDL is a subunit of the polymerase-associated factor 1 complex (Paf1C). It has a mass of approximately 64 kDa. LEO1 is expressed in many tissues with higher expression levels observed in the brain heart and skeletal muscle. This protein plays a role in the regulation of gene transcription by associating with RNA polymerase II. LEO1 is conserved across different species highlighting its importance in various biological processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nLEO1\/RDL contributes significantly to the transcription elongation process. As part of the larger Paf1 complex it interacts with other subunits to mediate histone modification influencing chromatin structure and gene expression. LEO1 regulates the transcription of various genes including those involved in cell growth and differentiation. Its presence is essential for the proper assembly and function of the Paf1 complex affecting the stability and activity of its associated proteins.\u003cbr\u003e\nPathways\u003cbr\u003e\nLEO1\/RDL plays a pivotal role in the regulation of the Wnt signaling pathway and RNA polymerase II transcription pathway. In the Wnt pathway LEO1 interacts with key proteins to influence gene transcription patterns necessary for cell fate determination and embryonic development. It also closely associates with Cdc73 and Paf1 proteins within its complex coordinating transcriptional regulation and chromatin remodeling steps ensuring accuracy and efficiency in gene expression processes.\u003cbr\u003e\nAlterations in LEO1\/RDL expression or function have been linked to cancer and developmental disorders. The aberrant regulation of LEO1 can disrupt normal transcriptional processes leading to unchecked cell proliferation and tumorigenesis. LEO1's interaction with Cdc73 a protein associated with the Hyperparathyroidism-jaw tumor syndrome can affect the manifestation of this disorder and related pathologies. Understanding the role of LEO1 in these contexts aids in developing targeted therapeutic approaches.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843881947305,"sku":"ab132311","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab132311","provider":"Iright","version":"1.0","type":"link"}